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Literature DB >> 15353600

The inositol polyphosphate 5-phosphatase Ocrl associates with endosomes that are partially coated with clathrin.

Alexander Ungewickell¹, Michael E Ward, Ernst Ungewickell, Philip W Majerus.

Abstract

The subcellular localization of Ocrl, the inositol polyphosphate 5-phosphatase that is mutated in Lowe syndrome, was investigated by fluorescence microscopy. Ocrl was localized to endosomes and Golgi membranes along with clathrin, giantin, the mannose 6-phosphate receptor, transferrin, and the early endosomal antigen 1 endosomal marker in fixed cells. The endosomal localization of Ocrl was confirmed by live-cell time-lapse microscopy in which we monitored the dynamics of Ocrl on endosomes. GST binding assays show that Ocrl interacts with the clathrin terminal domain and the clathrin adaptor protein AP-2. Our findings suggest a role for Ocrl in endosomal receptor trafficking and sorting.

Entities: Disease Gene

Mesh：

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Year: 2004 PMID： 15353600 PMCID： PMC518786 DOI： 10.1073/pnas.0405664101

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

30 in total

Review 1. The role of phosphatases in inositol signaling reactions.

Authors: P W Majerus; M V Kisseleva; F A Norris
Journal: J Biol Chem Date: 1999-04-16 Impact factor: 5.157

2. Hrs recruits clathrin to early endosomes.

Authors: C Raiborg; K G Bache; A Mehlum; E Stang; H Stenmark
Journal: EMBO J Date: 2001-09-03 Impact factor: 11.598

Review 3. Clathrin.

Authors: T Kirchhausen
Journal: Annu Rev Biochem Date: 2000 Impact factor: 23.643

10. The 5-phosphatase OCRL mediates retrograde transport of the mannose 6-phosphate receptor by regulating a Rac1-cofilin signalling module.

Authors: Vanessa A van Rahden; Kristina Brand; Juliane Najm; Joerg Heeren; Suzanne R Pfeffer; Thomas Braulke; Kerstin Kutsche
Journal: Hum Mol Genet Date: 2012-08-19 Impact factor: 6.150

The inositol polyphosphate 5-phosphatase Ocrl associates with endosomes that are partially coated with clathrin.

Review 1. The role of phosphatases in inositol signaling reactions.

2. Hrs recruits clathrin to early endosomes.

Review 3. Clathrin.

4. Ocrl1, a PtdIns(4,5)P(2) 5-phosphatase, is localized to the trans-Golgi network of fibroblasts and epithelial cells.

5. Mutation of the conserved domains of two inositol polyphosphate 5-phosphatases.

6. Increased levels of plasma lysosomal enzymes in patients with Lowe syndrome.

7. mu1A-adaptin-deficient mice: lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors.

8. Essential role of phosphoinositide metabolism in synaptic vesicle recycling.

9. Clathrin, adaptors and eps15 in endosomes containing activated epidermal growth factor receptors.

10. Dense core lysosomes can fuse with late endosomes and are re-formed from the resultant hybrid organelles.

1. OCRL1 modulates cilia length in renal epithelial cells.

2. Clathrin and clathrin-accessory proteins in rat kidney cortex epithelia.

3. Clathrin-dependent association of CVAK104 with endosomes and the trans-Golgi network.

4. A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism.

5. The AP-2 adaptor beta2 appendage scaffolds alternate cargo endocytosis.

6. A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway.

7. Abnormal bradykinin signalling in fibroblasts deficient in the PIP(2) 5-phosphatase, ocrl1.

Review 8. Peptide motifs: building the clathrin machinery.

Review 9. APPL1: role in adiponectin signaling and beyond.

10. The 5-phosphatase OCRL mediates retrograde transport of the mannose 6-phosphate receptor by regulating a Rac1-cofilin signalling module.