BACKGROUND: Circulating levels of B-type natriuretic peptide (BNP), a cardiac hormone, reflect the severity of cardiac dysfunction. Because the plasma BNP level changes dramatically during the period after the onset of acute myocardial infarction (AMI), identification of a suitable sampling time is problematic. There have been several reports indicating that the plasma BNP level obtained in the acute phase of AMI can be used as a prognostic marker. We examined whether the plasma BNP level measured 3 to 4 weeks after the onset of AMI represents a reliable prognostic marker for patients with AMI. METHODS AND RESULTS: We analyzed 145 consecutive patients with AMI. Plasma BNP levels were measured during the 3 to 4 weeks after onset of AMI. Of those patients, 23 experienced fatal cardiac events during this study. The mean follow-up period was 58.6 months. Log BNP, left ventricular end-diastolic pressure, and pulmonary vascular resistance were all significantly higher in the cardiac death group, and there were more men and more patients with a history of heart failure in the cardiac death group. A Cox proportional hazards model analysis showed that log BNP was an independent predictor of cardiac death. The survival rate was significantly higher in patients with log BNP <2.26 (180 pg/mL) than in those with log BNP > or =2.26. CONCLUSIONS: The plasma BNP level obtained 3 to 4 weeks after the onset of AMI can be used as an independent predictor of cardiac death in patients with AMI.
BACKGROUND: Circulating levels of B-type natriuretic peptide (BNP), a cardiac hormone, reflect the severity of cardiac dysfunction. Because the plasma BNP level changes dramatically during the period after the onset of acute myocardial infarction (AMI), identification of a suitable sampling time is problematic. There have been several reports indicating that the plasma BNP level obtained in the acute phase of AMI can be used as a prognostic marker. We examined whether the plasma BNP level measured 3 to 4 weeks after the onset of AMI represents a reliable prognostic marker for patients with AMI. METHODS AND RESULTS: We analyzed 145 consecutive patients with AMI. Plasma BNP levels were measured during the 3 to 4 weeks after onset of AMI. Of those patients, 23 experienced fatal cardiac events during this study. The mean follow-up period was 58.6 months. Log BNP, left ventricular end-diastolic pressure, and pulmonary vascular resistance were all significantly higher in the cardiac death group, and there were more men and more patients with a history of heart failure in the cardiac death group. A Cox proportional hazards model analysis showed that log BNP was an independent predictor of cardiac death. The survival rate was significantly higher in patients with log BNP <2.26 (180 pg/mL) than in those with log BNP > or =2.26. CONCLUSIONS: The plasma BNP level obtained 3 to 4 weeks after the onset of AMI can be used as an independent predictor of cardiac death in patients with AMI.
Authors: Massimo Volpe; Pietro Francia; Giuliano Tocci; Speranza Rubattu; Sara Cangianiello; Maria Assunta Elena Rao; Bruno Trimarco; Mario Condorelli Journal: Clin Cardiol Date: 2010-11 Impact factor: 2.882
Authors: Parveen K Garg; Faye L Norby; Wendy Wang; Darshan Krishnappa; Elsayed Z Soliman; Pamela L Lutsey; Elizabeth Selvin; Christie M Ballantyne; Alvaro Alonso; Lin Y Chen Journal: Am J Cardiol Date: 2021-08-28 Impact factor: 2.778
Authors: Leonardo De Luca; Gregg C Fonarow; Kirkwood F Adams; Alexandre Mebazaa; Luigi Tavazzi; Karl Swedberg; Mihai Gheorghiade Journal: Heart Fail Rev Date: 2007-06 Impact factor: 4.654
Authors: Marco Budeus; Emanuel Salibassoglu; Anna Maria Schymura; Nico Reinsch; Heinrich Wieneke; Stefan Sack; Raimund Erbel Journal: Indian Pacing Electrophysiol J Date: 2007-10-22