Literature DB >> 15351790

Forefront of Na+/Ca2+ exchanger studies: regulation kinetics of Na+/Ca2+ exchangers.

Satoshi Matsuoka1.   

Abstract

Five isoforms of Na+/Ca2+ exchanger have been identified: NCX1, NCX2, NCX3, NCX-SQ1, and CALX. In all of the exchangers, the Na+/Ca2+ exchange current, which was recorded in inside-out membrane patches, was regulated by cytoplasmic Ca2+. However, the mode of regulation is different among the exchangers. NCX1, NCX2, and NCX-SQ1 are positively regulated by cytoplasmic Ca2+, but CALX is negatively regulated. NCX3 apparently has both positive and negative regulation mechanisms. In this review, I briefly summarize the Ca2+ -dependent regulation mechanisms of the exchangers.

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Year:  2004        PMID： 15351790     DOI： 10.1254/jphs.fmj04002x2

Source DB:  PubMed          Journal:  J Pharmacol Sci        ISSN： 1347-8613            Impact factor:   3.337


  4 in total

Review 1.  Modulation of the cardiac Na+-Ca2+ exchanger by cytoplasmic protons: Molecular mechanisms and physiological implications.

Authors:  Kyle Scranton; Scott John; Ariel Escobar; Joshua I Goldhaber; Michela Ottolia
Journal:  Cell Calcium       Date:  2019-12-11       Impact factor: 6.817

2.  Expression of alternatively spliced variants of Na-Ca-exchanger-1 in experimental colitis: role in reduced colonic contractility.

Authors:  M Shubair; M A Oriowo; I Khan
Journal:  Mol Cell Biochem       Date:  2012-07-20       Impact factor: 3.396

3.  Calcium-Dependent Regulation of Ion Channels.

Authors:  Vikas N Shah; Benjamin Chagot; Walter J Chazin
Journal:  Calcium Bind Proteins       Date:  2006 Oct-Dec

Review 4.  Sodium-Calcium Exchangers of the SLC8 Family in Oligodendrocytes: Functional Properties in Health and Disease.

Authors:  Samantha A Spencer; Edna Suárez-Pozos; Miguel Escalante; Yu Par Myo; Babette Fuss
Journal:  Neurochem Res       Date:  2020-01-11       Impact factor: 3.996
  4 in total

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