| Literature DB >> 15351395 |
Lee D Jennings1, Kenneth W Foreman, Thomas S Rush, Desiree H H Tsao, Lidia Mosyak, Scott L Kincaid, Mohani N Sukhdeo, Alan G Sutherland, Weidong Ding, Cynthia Hess Kenny, Chantel L Sabus, Hanlan Liu, Elizabeth G Dushin, Soraya L Moghazeh, Pornpen Labthavikul, Peter J Petersen, Margareta Tuckman, Steven A Haney, Alexey V Ruzin.
Abstract
The ZipA-FtsZ protein-protein interaction is a potential target for antibacterial therapy. The design and parallel synthesis of a combinatorial library of small molecules, which target the FtsZ binding area on ZipA are described. Compounds were demonstrated to bind to the FtsZ binding domain of ZipA by HSQC NMR and to inhibit cell division in a cell elongation assay.Entities:
Mesh：
Substances：
Year: 2004 PMID： 15351395 DOI： 10.1016/j.bmc.2004.07.031
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641