| Literature DB >> 15351107 |
A Attawish1, S Chivapat, S Phadungpat, J Bansiddhi, Y Techadamrongsin, O Mitrijit, B Chaorai, P Chavalittumrong.
Abstract
The effect of water extract of Gynostemma pentaphyllum was evaluated on 6-month chronic toxicity in Wistar rats. Control group received orally 10 ml kg(-1) day(-1). The extract was orally given to the five treatment groups at the doses of 6, 30, 150, 750 and 750 mg kg(-1) day(-1) for 24 weeks. The last group served as the recovery group. The results showed that the extract did not produce any significant dose-related changes. Therefore, it is concluded that the extract of G. pentaphyllum at the given doses did not produce any significant toxic effect in rats during 6-month period of the treatment.Entities:
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Year: 2004 PMID： 15351107 DOI： 10.1016/j.fitote.2004.04.010
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882