Literature DB >> 15350974

Checkpoints in ER-associated degradation: excuse me, which way to the proteasome?

Annette Ahner1, Jeffrey L Brodsky.   

Abstract

The failure of secreted proteins to fold results in their retrotranslocation from the endoplasmic reticulum (ER) and degradation by the proteasome in a process called "ER-associated degradation" (ERAD). Two recent studies indicate that ERAD substrates are targeted to different pathways depending on the topology of the substrate and the subcellular location of the misfolded domain.

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Year:  2004        PMID： 15350974     DOI： 10.1016/j.tcb.2004.07.013

Source DB:  PubMed          Journal:  Trends Cell Biol        ISSN： 0962-8924            Impact factor:   20.808


  44 in total

1.  Liver cytochrome P450 3A endoplasmic reticulum-associated degradation: a major role for the p97 AAA ATPase in cytochrome P450 3A extraction into the cytosol.

Authors:  Poulomi Acharya; Mingxiang Liao; Juan C Engel; Maria Almira Correia
Journal:  J Biol Chem       Date:  2010-11-24       Impact factor: 5.157

2.  Aggregated myocilin induces russell bodies and causes apoptosis: implications for the pathogenesis of myocilin-caused primary open-angle glaucoma.

Authors:  Gary Hin-Fai Yam; Katarina Gaplovska-Kysela; Christian Zuber; Jürgen Roth
Journal:  Am J Pathol       Date:  2007-01       Impact factor: 4.307

Review 3.  The activities and function of molecular chaperones in the endoplasmic reticulum.

Authors:  Teresa M Buck; Christine M Wright; Jeffrey L Brodsky
Journal:  Semin Cell Dev Biol       Date:  2007-09-08       Impact factor: 7.727

4.  Ubx4 modulates cdc48 activity and influences degradation of misfolded proteins of the endoplasmic reticulum.

Authors:  Sven M Alberts; Caroline Sonntag; Antje Schäfer; Dieter H Wolf
Journal:  J Biol Chem       Date:  2009-04-09       Impact factor: 5.157

5.  In vitro analysis of Hrd1p-mediated retrotranslocation of its multispanning membrane substrate 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase.

Authors:  Renee M Garza; Brian K Sato; Randolph Y Hampton
Journal:  J Biol Chem       Date:  2009-03-26       Impact factor: 5.157

6.  VCP/p97 AAA-ATPase does not interact with the endogenous wild-type cystic fibrosis transmembrane conductance regulator.

Authors:  Rebecca F Goldstein; Ashutosh Niraj; Todd P Sanderson; Landon S Wilson; Andras Rab; Helen Kim; Zsuzsa Bebok; James F Collawn
Journal:  Am J Respir Cell Mol Biol       Date:  2007-02-01       Impact factor: 6.914

7.  Huntingtin interacts with the cue domain of gp78 and inhibits gp78 binding to ubiquitin and p97/VCP.

Authors:  Hui Yang; Chao Liu; Yongwang Zhong; Shouqing Luo; Mervyn J Monteiro; Shengyun Fang
Journal:  PLoS One       Date:  2010-01-26       Impact factor: 3.240

8.  The Neurospora peptide:N-glycanase ortholog PNG1 is essential for cell polarity despite its lack of enzymatic activity.

Authors:  Sabine Maerz; Yoko Funakoshi; Yuki Negishi; Tadashi Suzuki; Stephan Seiler
Journal:  J Biol Chem       Date:  2009-11-25       Impact factor: 5.157

9.  Chaperone requirements for biosynthesis of the trypanosome variant surface glycoprotein.

Authors:  Mark C Field; Tatiana Sergeenko; Ya-Nan Wang; Susanne Böhm; Mark Carrington
Journal:  PLoS One       Date:  2010-01-05       Impact factor: 3.240

10.  Calnexin regulates apoptosis induced by inositol starvation in fission yeast.

Authors:  Renée Guérin; Pascale B Beauregard; Alexandre Leroux; Luis A Rokeach
Journal:  PLoS One       Date:  2009-07-16       Impact factor: 3.240
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