Literature DB >> 15350696

Galanin inhibits gastric acid secretion through a somatostatin-independent mechanism in mice.

Laura Piqueras1, Yvette Taché, Vicente Martinez.   

Abstract

The role of somatostatin in galanin-induced inhibition of gastric acid secretion in urethane-anesthetized mice was investigated by using immunoneutralization of endogenous somatostatin and somatostatin receptor type 2 (SSTR2) knockout mice. Intravenous galanin (10 and 20 microg/kg/h) inhibited pentagastrin-stimulated gastric acid secretion by 47 and 33%, respectively. Somatostatin antibody injected i.v. increased acid secretion by 3.5-fold over basal levels but did not modify the antisecretory effects of galanin. Urethane-anesthetized SSTR2 knockout mice had a basal secretion 14-fold higher than wild-type animals, that was inhibited by galanin (10 and 20 microg/kg/h) by 49 and 31% respectively. In mice galanin inhibits gastric acid secretion through a somatostatin-independent mechanism.

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Year:  2004        PMID： 15350696     DOI： 10.1016/j.peptides.2004.06.003

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  7 in total

1.  Role of somatostatin receptors on gastric acid secretion in wild-type and somatostatin receptor type 2 knockout mice.

Authors:  Laura Piqueras; Vicente Martínez
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2004-11-20       Impact factor: 3.000

2.  Control of gastric acid secretion in somatostatin receptor 2 deficient mice: shift from endocrine/paracrine to neurocrine pathways.

Authors:  Chun-Mei Zhao; Vicente Martinez; Laura Piqueras; Lixin Wang; Yvette Taché; Duan Chen
Journal:  Endocrinology       Date:  2007-11-01       Impact factor: 4.736

3.  Modulation of the main porcine enteric neuropeptides by a single low-dose of lipopolysaccharide (LPS) Salmonella Enteritidis.

Authors:  Anita Mikołajczyk; Sławomir Gonkowski; Dagmara Złotkowska
Journal:  Gut Pathog       Date:  2017-12-12       Impact factor: 4.181

4.  Distribution and Neurochemistry of the Porcine Ileocaecal Valve Projecting Sensory Neurons in the Dorsal Root Ganglia and the Influence of Lipopolysaccharide from Different Serotypes of Salmonella spp. on the Chemical Coding of DRG Neurons in the Cell Cultures.

Authors:  Anita Mikołajczyk; Anna Kozłowska; Sławomir Gonkowski
Journal:  Int J Mol Sci       Date:  2018-08-28       Impact factor: 5.923

Review 5.  Mycotoxins and the Enteric Nervous System.

Authors:  Sławomir Gonkowski; Magdalena Gajęcka; Krystyna Makowska
Journal:  Toxins (Basel)       Date:  2020-07-19       Impact factor: 4.546

6.  Neurochemical characterization of zinc transporter 3-like immunoreactive (ZnT3(+)) neurons in the intramural ganglia of the porcine duodenum.

Authors:  Joanna Wojtkiewicz; Sławomir Gonkowski; Maciej Równiak; Robert Crayton; Mariusz Majewski; Marek Jałyński
Journal:  J Mol Neurosci       Date:  2012-07-12       Impact factor: 3.444

7.  Chemical coding of zinc-enriched neurons in the intramural ganglia of the porcine jejunum.

Authors:  Joanna Wojtkiewicz; Maciej Równiak; Robert Crayton; Mariusz Majewski; Sławomir Gonkowski
Journal:  Cell Tissue Res       Date:  2012-08-24       Impact factor: 5.249
  7 in total

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