Literature DB >> 15348794

Release of tobramycin from tobramycin-containing bone cement in bone and serum of rabbits.

M W Nijhof1, W J Dhert, P B Tilman, A J Verbout, A Fleer.   

Abstract

Tobramycin release from tobramycin-containing bone cement was studied in vivo in a rabbit model. After insertion of cement into the right femur, tobramycin concentration as a function of time for up to 28 days was measured in serum and bone of rabbits. Tobramycin release in the femoral cortex adjacent to the cement was found to exceed the minimal inhibitory concentration for Staphylococcus aureus Wood 46. Serum tobramycin concentrations were below the systemic toxicity threshold.

Entities:  

Year:  1997        PMID： 15348794     DOI： 10.1023/a:1018577032259

Source DB:  PubMed          Journal:  J Mater Sci Mater Med        ISSN： 0957-4530            Impact factor:   3.896


  20 in total

1.  Evaluation of the E test, a novel method of quantifying antimicrobial activity.

Authors:  D F Brown; L Brown
Journal:  J Antimicrob Chemother       Date:  1991-02       Impact factor: 5.790

2.  Antibiotic-acrylic bone cement composites. Studies of gentamicin and Palacos.

Authors:  D J Schurman; C Trindade; H P Hirshman; K Moser; G Kajiyama; P Stevens
Journal:  J Bone Joint Surg Am       Date:  1978-10       Impact factor: 5.284

3.  Interaction of tobramycin and pH in cultured chick tibiae.

Authors:  T Murakami; H Murakami; W K Ramp; E N Hanley
Journal:  J Orthop Res       Date:  1996-09       Impact factor: 3.494

4.  The release in vitro of vancomycin and tobramycin from acrylic bone cement.

Authors:  P Seyral; A Zannier; J N Argenson; D Raoult
Journal:  J Antimicrob Chemother       Date:  1994-02       Impact factor: 5.790

5.  Leaching out from acrylic bone cement. Experimental evaluation.

Authors:  B M Wroblewski
Journal:  Clin Orthop Relat Res       Date:  1977-05       Impact factor: 4.176

6.  Antibiotic-impregnated acrylic bone cement.

Authors:  K E Marks; C L Nelson; E P Lautenschlager
Journal:  J Bone Joint Surg Am       Date:  1976-04       Impact factor: 5.284

7.  In vitro and in vivo evaluation of antibiotic diffusion from antibiotic-impregnated polymethylmethacrylate beads.

Authors:  K Adams; L Couch; G Cierny; J Calhoun; J T Mader
Journal:  Clin Orthop Relat Res       Date:  1992-05       Impact factor: 4.176

8.  Tobramycin-impregnated cement in total hip replacements.

Authors:  J W Pritchett; D T Bortel
Journal:  Orthop Rev       Date:  1992-05

9.  Antibiotic impregnated bone cement in total hip arthroplasty. An in vivo comparison of the elution properties of tobramycin and vancomycin.

Authors:  W W Brien; E A Salvati; R Klein; B Brause; S Stern
Journal:  Clin Orthop Relat Res       Date:  1993-11       Impact factor: 4.176

10.  Vancomycin vs tobramycin elution from polymethylmethacrylate: an in vitro study.

Authors:  K J Lawson; K E Marks; J Brems; S Rehm
Journal:  Orthopedics       Date:  1990-05       Impact factor: 1.390
View more
  2 in total

1.  Spatiotemporal quantification of local drug delivery using MRI.

Authors:  Morgan B Giers; Alex C McLaren; Jonathan D Plasencia; David Frakes; Ryan McLemore; Michael R Caplan
Journal:  Comput Math Methods Med       Date:  2013-04-24       Impact factor: 2.238

Review 2.  Quaternized chitosan as an antimicrobial agent: antimicrobial activity, mechanism of action and biomedical applications in orthopedics.

Authors:  Honglue Tan; Rui Ma; Chucheng Lin; Ziwei Liu; Tingting Tang
Journal:  Int J Mol Sci       Date:  2013-01-16       Impact factor: 5.923
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.