| Literature DB >> 15348551 |
Y-S Cho1, J-W Lee, J-S Lee, J H Lee, T R Yoon, Y Kuroyanagi, M H Park, D G Pyun, H J Kim.
Abstract
Five different kinds of PU foam wound dressings were prepared to investigate their wound healing capability. They include (i) PU+silver sulfadiazine (AgSD), (ii) PU+alginate (Al), (iii) PU+Al+AgSD, (i.v.) PU+hyaluronic acid (HA), and (v) PU+HA+AgSD. Physical properties and in vitro behaviors of AgSD release and fibroblast adhesion on those dressings were evaluated. From the drug release and fibroblast adhesion studies, it was observed that PU foam impregnated with both HA and AgSD shows good drug release behavior and low adhesion of the cells. Furthermore, the HA and AgSD-containing PU foam showed excellent wound healing effect without any inflammation or yellow cluster. The wound size decreased around 77% after 1 week application of that foam dressing onto a rat skin defect.Entities:
Year: 2002 PMID: 15348551 DOI: 10.1023/a:1016500429225
Source DB: PubMed Journal: J Mater Sci Mater Med ISSN: 0957-4530 Impact factor: 3.896