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Literature DB >> 15348428

Synthesis and biocompatibility of porous nano-hydroxyapatite/collagen/alginate composite.

S M Zhang¹, F Z Cui, S S Liao, Y Zhu, L Han.

Abstract

Porous nano-hydroxyapatite/collagen/alginate (nHAC/Alginate) composite containing nHAC and Ca-crosslinked alginate is synthesized biomimetically. This composite shows a significant improvement in mechanical properties over nHAC material. Mechanical test results show that the compressive modulus and yield strength of this composite are in direct proportion to the percentage of Ca-crosslinked alginate in the composite. Primary biocompatibility experiments in vitro including fibroblasts and osteoblasts co-culture with nHAC/alginate composite indicated the high biocompatibility of this composite. Therefore the composite can be a promising candidate of scaffold material for bone tissue engineering.

Entities: Chemical

Year: 2003 PMID： 15348428 DOI： 10.1023/a:1024083309982

Source DB: PubMed Journal: J Mater Sci Mater Med ISSN： 0957-4530 Impact factor: 3.896

15 in total

1. Self-organization mechanism in a bone-like hydroxyapatite/collagen nanocomposite synthesized in vitro and its biological reaction in vivo.

Authors: M Kikuchi; S Itoh; S Ichinose; K Shinomiya; J Tanaka
Journal: Biomaterials Date: 2001-07 Impact factor: 12.479

2. The quantitative histochemistry of brain. II. Enzyme measurements.

Authors: O H LOWRY; N R ROBERTS; M L WU; W S HIXON; E J CRAWFORD
Journal: J Biol Chem Date: 1954-03 Impact factor: 5.157

3. Tissue response to nano-hydroxyapatite/collagen composite implants in marrow cavity.

Authors: C Du; F Z Cui; Q L Feng; X D Zhu; K de Groot
Journal: J Biomed Mater Res Date: 1998-12-15

4. The biocompatibility and osteoconductive activity of a novel hydroxyapatite/collagen composite biomaterial, and its function as a carrier of rhBMP-2.

Authors: S Itoh; M Kikuchi; K Takakuda; Y Koyama; H N Matsumoto; S Ichinose; J Tanaka; T Kawauchi; K Shinomiya
Journal: J Biomed Mater Res Date: 2001-03-05

5. Formation of calcium phosphate/collagen composites through mineralization of collagen matrix.

Authors: C Du; F Z Cui; W Zhang; Q L Feng; X D Zhu; K de Groot
Journal: J Biomed Mater Res Date: 2000-06-15

6. Alginate as a chondrocyte-delivery substance in combination with a non-woven scaffold for cartilage tissue engineering.

Authors: Willem J C M Marijnissen; Gerjo J V M van Osch; Joachim Aigner; Simone W van der Veen; Anthony P Hollander; Henriëtte L Verwoerd-Verhoef; Jan A N Verhaar
Journal: Biomaterials Date: 2002-03 Impact factor: 12.479

7. Hydroxyapatite-clay bone fixation for loaded implants.

Authors: M Maruyama
Journal: J Biomed Mater Res Date: 1995-06

8. Injectable alginate seeded with chondrocytes as a potential treatment for vesicoureteral reflux.

Authors: A Atala; L G Cima; W Kim; K T Paige; J P Vacanti; A B Retik; C A Vacanti
Journal: J Urol Date: 1993-08 Impact factor: 7.450

9. Osteogenesis in marrow-derived mesenchymal cell porous ceramic composites transplanted subcutaneously: effect of fibronectin and laminin on cell retention and rate of osteogenic expression.

Authors: J E Dennis; S E Haynesworth; R G Young; A I Caplan
Journal: Cell Transplant Date: 1992 Impact factor: 4.064

Synthesis and biocompatibility of porous nano-hydroxyapatite/collagen/alginate composite.

1. Self-organization mechanism in a bone-like hydroxyapatite/collagen nanocomposite synthesized in vitro and its biological reaction in vivo.

2. The quantitative histochemistry of brain. II. Enzyme measurements.

3. Tissue response to nano-hydroxyapatite/collagen composite implants in marrow cavity.

4. The biocompatibility and osteoconductive activity of a novel hydroxyapatite/collagen composite biomaterial, and its function as a carrier of rhBMP-2.

5. Formation of calcium phosphate/collagen composites through mineralization of collagen matrix.

6. Alginate as a chondrocyte-delivery substance in combination with a non-woven scaffold for cartilage tissue engineering.

7. Hydroxyapatite-clay bone fixation for loaded implants.

8. Injectable alginate seeded with chondrocytes as a potential treatment for vesicoureteral reflux.

9. Osteogenesis in marrow-derived mesenchymal cell porous ceramic composites transplanted subcutaneously: effect of fibronectin and laminin on cell retention and rate of osteogenic expression.

10. Osteoblast responses to orthopedic implant materials in vitro.

Review 1. Biocomposites and hybrid biomaterials based on calcium orthophosphates.

2. Hydrogels That Allow and Facilitate Bone Repair, Remodeling, and Regeneration.

3. Viscoelastic properties of mineralized alginate hydrogel beads.

Review 4. Nanostructured materials for applications in drug delivery and tissue engineering.

5. Preparation and characterization of hydroxyapatite/polycaprolactone-chitosan composites.

Review 6. Calcium Orthophosphate-Containing Biocomposites and Hybrid Biomaterials for Biomedical Applications.

Review 7. Nanostructured bioceramics for maxillofacial applications.

8. Collagen-based scaffolds for skin tissue engineering.

9. Injectable biocomposites for bone healing in rabbit femoral condyle defects.

10. Enhanced in vitro osteoblast differentiation on TiO2 scaffold coated with alginate hydrogel containing simvastatin.