Janelle M Wheat1, Geoffrey M Currie. 1. School of Clinical Sciences, Charles Sturt University, Wagga Wagga, New South Wales, Australia. jwheat@csu.edu.au
Abstract
OBJECTIVE: Advances in 99mTc-based radiopharmaceuticals and multiple-detector gantries have the potential to increase the significance of patient motion on the diagnostic integrity of myocardial perfusion SPECT acquisitions. METHODS: An experimental study was used to evaluate the effect of various patient motions on the diagnostic integrity of myocardial perfusion SPECT data using 522 motion simulations generated from a technically and diagnostically normal dataset. RESULTS: Of studies with induced motion, 21.7% of simulated motion demonstrated motion-induced artifacts. Abrupt motion resulted in artifacts for 52.6% of studies, whereas bounce motion resulted in artifacts in 6.8% of studies. The locations where motion resulted in the most studies with artifacts were at 45 degrees (36.1%) and 75 degrees (32.4%). No statistical difference was demonstrated between single, dual-, and triple-head configurations. CONCLUSION: Combining these results with those of the clinical evaluation of incidence indicates that patient motion during 99mTc-based myocardial perfusion SPECT studies is a potential source of false-positive findings for coronary artery disease. There is a 7.1% probability that myocardial perfusion SPECT studies performed at the 3 sites investigated will contain a motion-induced artifact. Fully realized, this potential results in decreased test specificity and unfavorable cost and consequence outcomes.
OBJECTIVE: Advances in 99mTc-based radiopharmaceuticals and multiple-detector gantries have the potential to increase the significance of patient motion on the diagnostic integrity of myocardial perfusion SPECT acquisitions. METHODS: An experimental study was used to evaluate the effect of various patient motions on the diagnostic integrity of myocardial perfusion SPECT data using 522 motion simulations generated from a technically and diagnostically normal dataset. RESULTS: Of studies with induced motion, 21.7% of simulated motion demonstrated motion-induced artifacts. Abrupt motion resulted in artifacts for 52.6% of studies, whereas bounce motion resulted in artifacts in 6.8% of studies. The locations where motion resulted in the most studies with artifacts were at 45 degrees (36.1%) and 75 degrees (32.4%). No statistical difference was demonstrated between single, dual-, and triple-head configurations. CONCLUSION: Combining these results with those of the clinical evaluation of incidence indicates that patient motion during 99mTc-based myocardial perfusion SPECT studies is a potential source of false-positive findings for coronary artery disease. There is a 7.1% probability that myocardial perfusion SPECT studies performed at the 3 sites investigated will contain a motion-induced artifact. Fully realized, this potential results in decreased test specificity and unfavorable cost and consequence outcomes.
Authors: Michael A King; Joyoni Dey; Karen Johnson; Paul Dasari; Joyeeta M Mukherjee; Joseph E McNamara; Arda Konik; Cliff Lindsay; Shaokuan Zheng; Dennis Coughlin Journal: Med Phys Date: 2013-11 Impact factor: 4.071
Authors: Joyeeta Mitra Mukherjee; Karen L Johnson; Joseph E McNamara; Michael A King Journal: IEEE Trans Nucl Sci Date: 2010-06-01 Impact factor: 1.679