Literature DB >> 1534652

Demonstration of inhibitory guanine nucleotide regulatory protein (Gi) function in liver and hepatocyte membranes from streptozotocin-treated rats.

D M Kirkham1, G J Murphy, P Young.   

Abstract

By using a defined plasma-membrane preparation, functional inhibition of adenylate cyclase activity by the inhibitory G-protein (Gi) was observed in liver and hepatocyte membranes from rats made diabetic by streptozotocin. These observations contrast with previous reports which have shown a defect in Gi in this diabetic animal model. These results suggest that Gi function is not impaired in the livers of streptozotocin-treated rats and that plasma-membrane preparation procedures should be clearly defined before ascribing Gi defects to a pathological state such as diabetes.

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Year:  1992        PMID： 1534652      PMCID： PMC1132637          DOI： 10.1042/bj2840301

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  20 in total

1.  Evaluation of inhibitory guanine nucleotide regulatory protein Gi function in hepatocyte and liver membranes from obese Zucker (fa/fa) rats and their lean (Fa/?) littermates.

Authors:  P Young; D M Kirkham; G J Murphy; M A Cawthorne
Journal:  Diabetologia       Date:  1991-08       Impact factor: 10.122

2.  P2-purinergic receptors are coupled to two signal transduction systems leading to inhibition of cAMP generation and to production of inositol trisphosphate in rat hepatocytes.

Authors:  F Okajima; Y Tokumitsu; Y Kondo; M Ui
Journal:  J Biol Chem       Date:  1987-10-05       Impact factor: 5.157

3.  Forskolin-activated adenylate cyclase. Inhibition by guanyl-5'-yl imidodiphosphate.

Authors:  T H Hudson; J N Fain
Journal:  J Biol Chem       Date:  1983-08-25       Impact factor: 5.157

4.  The glucagon receptor of rat liver plasma membrane can couple to adenylate cyclase without activating it.

Authors:  M D Houslay; J C Metcalfe; G B Warren; T R Hesketh; G A Smith
Journal:  Biochim Biophys Acta       Date:  1976-06-17

5.  Diabetes-induced changes in guanine-nucleotide-regulatory-protein mRNA detected using synthetic oligonucleotide probes.

Authors:  S L Griffiths; J T Knowler; M D Houslay
Journal:  Eur J Biochem       Date:  1990-10-24

6.  Diabetes abolishes the GTP-dependent, but not the receptor-dependent inhibitory function of the inhibitory guanine-nucleotide-binding regulatory protein (Gi) on adipocyte adenylate cyclase activity.

Authors:  D Strassheim; G Milligan; M D Houslay
Journal:  Biochem J       Date:  1990-03-01       Impact factor: 3.857

7.  Multiple defects occur in the guanine nucleotide regulatory protein system in liver plasma membranes of obese (fa/fa) but not lean (Fa/Fa) Zucker rats: loss of functional Gi and abnormal Gs function.

Authors:  M D Houslay; D J Gawler; G Milligan; A Wilson
Journal:  Cell Signal       Date:  1989       Impact factor: 4.315

8.  Diabetes-induced alterations in the expression, functioning and phosphorylation state of the inhibitory guanine nucleotide regulatory protein Gi-2 in hepatocytes.

Authors:  M Bushfield; S L Griffiths; G J Murphy; N J Pyne; J T Knowler; G Milligan; P J Parker; S Mollner; M D Houslay
Journal:  Biochem J       Date:  1990-10-15       Impact factor: 3.857

9.  Abolition of the expression of inhibitory guanine nucleotide regulatory protein Gi activity in diabetes.

Authors:  D Gawler; G Milligan; A M Spiegel; C G Unson; M D Houslay
Journal:  Nature       Date:  1987 May 21-27       Impact factor: 49.962

10.  Guanine nucleotide binding regulatory proteins and adenylate cyclase in livers of streptozotocin- and BB/Wor-diabetic rats. Immunodetection of Gs and Gi with antisera prepared against synthetic peptides.

Authors:  C J Lynch; P F Blackmore; E H Johnson; R L Wange; P K Krone; J H Exton
Journal:  J Clin Invest       Date:  1989-06       Impact factor: 14.808
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  3 in total

1.  Reversal of defective G-proteins and adenylyl cyclase/cAMP signal transduction in diabetic rats by vanadyl sulphate therapy.

Authors:  M B Anand-Srivastava; J H McNeill; X P Yang
Journal:  Mol Cell Biochem       Date:  1995 Dec 6-20       Impact factor: 3.396

2.  The effects of propionate and valerate on insulin responsiveness for glucose uptake in 3T3-L1 adipocytes and C2C12 myotubes via G protein-coupled receptor 41.

Authors:  Joo-Hui Han; In-Su Kim; Sang-Hyuk Jung; Sang-Gil Lee; Hwa-Young Son; Chang-Seon Myung
Journal:  PLoS One       Date:  2014-04-18       Impact factor: 3.240

Review 3.  The functional state of hormone-sensitive adenylyl cyclase signaling system in diabetes mellitus.

Authors:  Alexander O Shpakov; Kira V Derkach
Journal:  J Signal Transduct       Date:  2013-09-28
  3 in total

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