BACKGROUND: During the winter of 2002-2003, the Israeli health authorities launched a campaign to vaccinate first responders against smallpox. METHODS: In an open study, 159 healthy, preimmunized adults, 24-52 years old, who participated in the campaign were vaccinated with the Lister strain of vaccinia virus by the multipuncture technique. The safety, immunogenicity, and reactogenicity of the vaccine were assessed. RESULTS: Successful vaccination rates were 61% and 56%, on the basis of clinical take and seroconversion, respectively. Adverse events among the vaccinees were minor. Seventy-nine (88%) of the 90 vaccinees with clinical take also seroconverted ( kappa =0.779). The level of preexisting antibodies inversely correlated with the rates of clinical take and seroconversion (P</=.0098). In the group of vaccinees with the lowest preexisting levels of antibodies, 89% and 86% developed clinical take or seroconverted, respectively. The time since last vaccination was significantly associated with the rates of clinical take and seroconversion (P</=0.001). CONCLUSIONS: These rates of successful vaccination in previously immunized individuals are consistent with the historical experience of use of this vaccine in Israel. The rate of occurrence and the severity of local and other reactions in the vaccinees were within the expected range. Levels of preexisting antibodies and the time since last vaccination played a major role in determining success rates.
BACKGROUND: During the winter of 2002-2003, the Israeli health authorities launched a campaign to vaccinate first responders against smallpox. METHODS: In an open study, 159 healthy, preimmunized adults, 24-52 years old, who participated in the campaign were vaccinated with the Lister strain of vaccinia virus by the multipuncture technique. The safety, immunogenicity, and reactogenicity of the vaccine were assessed. RESULTS: Successful vaccination rates were 61% and 56%, on the basis of clinical take and seroconversion, respectively. Adverse events among the vaccinees were minor. Seventy-nine (88%) of the 90 vaccinees with clinical take also seroconverted ( kappa =0.779). The level of preexisting antibodies inversely correlated with the rates of clinical take and seroconversion (P</=.0098). In the group of vaccinees with the lowest preexisting levels of antibodies, 89% and 86% developed clinical take or seroconverted, respectively. The time since last vaccination was significantly associated with the rates of clinical take and seroconversion (P</=0.001). CONCLUSIONS: These rates of successful vaccination in previously immunized individuals are consistent with the historical experience of use of this vaccine in Israel. The rate of occurrence and the severity of local and other reactions in the vaccinees were within the expected range. Levels of preexisting antibodies and the time since last vaccination played a major role in determining success rates.
Authors: Josef Mayrhofer; Sogue Coulibaly; Annett Hessel; Georg W Holzer; Michael Schwendinger; Peter Brühl; Marijan Gerencer; Brian A Crowe; Shen Shuo; Wanjing Hong; Yee Joo Tan; Barbara Dietrich; Nicolas Sabarth; Helga Savidis-Dacho; Otfried Kistner; P Noel Barrett; Falko G Falkner Journal: J Virol Date: 2009-03-11 Impact factor: 5.103
Authors: Dennis D Taub; William B Ershler; Mark Janowski; Andrew Artz; Michael L Key; Julie McKelvey; Denis Muller; Bernard Moss; Luigi Ferrucci; Patricia L Duffey; Dan L Longo Journal: Am J Med Date: 2008-12 Impact factor: 4.965
Authors: Bruno E F Mota; Nadia Gallardo-Romero; Giliane Trindade; M Shannon Keckler; Kevin Karem; Darin Carroll; Marco A Campos; Leda Q Vieira; Flávio G da Fonseca; Paulo C P Ferreira; Cláudio A Bonjardim; Inger K Damon; Erna G Kroon Journal: PLoS One Date: 2011-04-15 Impact factor: 3.240
Authors: Clement A Meseda; Joseph Campbell; Arunima Kumar; Alonzo D Garcia; Michael Merchlinsky; Jerry P Weir Journal: PLoS One Date: 2013-06-13 Impact factor: 3.240