| Literature DB >> 15346332 |
Conrad P Quinn1, Peter M Dull, Vera Semenova, Han Li, Shane Crotty, Thomas H Taylor, Evelene Steward-Clark, Karen L Stamey, Daniel S Schmidt, Kelly Wallace Stinson, Alison E Freeman, Cheryl M Elie, Sandra K Martin, Carolyn Greene, Rachael D Aubert, John Glidewell, Bradley A Perkins, Rafi Ahmed, David S Stephens.
Abstract
Anti-protective antigen (PA) immunoglobulin (Ig) G, toxin neutralization, and PA-specific IgG memory B cell responses were studied in patients with bioterrorism-related cutaneous or inhalation anthrax and in a patient with laboratory-acquired cutaneous anthrax. Responses were determined for >1 year after the onset of symptoms. Eleven days after the onset of symptoms (15 days after likely exposure), anti-PA IgG was detected in 16 of 17 patients with confirmed or suspected clinical anthrax who were tested. Anti-PA IgG remained detectable 8-16 months after the onset of symptoms in all 6 survivors of inhalation anthrax and in 7 of 11 survivors of cutaneous anthrax who were tested. Anti-PA IgG levels and serum toxin neutralizing activity were strongly associated (R2=0.83). PA-specific IgG memory B cells were detectable in all 6 survivors of inhalation anthrax but in only 2 of 7 patients with cutaneous anthrax who were tested. Anti-PA IgG is an important diagnostic marker of anthrax, a predictor of serum anti-toxin activity, and a marker of immunological memory against anthrax.Entities:
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Year: 2004 PMID： 15346332 DOI： 10.1086/423937
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226