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Literature DB >> 15346169

Does Serotonin Play a Role in Epilepsy?

Abstract

Studies in experimental models have suggested a potential role for serotonergic transmission in epilepsy, and interest in this research has been increased by the development of positron emission tomography (PET) ligands that can be used to study 5-hydroxytryptamine (5-HT) receptors and transporters. The serotonergic system is very complex. At least 13 distinct G protein-coupled 5-HT receptors and one ligand-gated ion channel receptor (5-HT(3)) are divided into seven distinct classes (5-HT(1) to 5-HT(7)) ((1)). The receptors vary widely in their distribution and effects, innervating vascular structures and gut smooth muscle as well as neuronal tissue. Several receptor subtypes may be relevant to epilepsy.

Entities: Chemical Disease

Year: 2003 PMID： 15346169 PMCID： PMC321211 DOI： 10.1046/j.1535-7597.2003.03508.x

Source DB: PubMed Journal: Epilepsy Curr ISSN： 1535-7511 Impact factor: 7.500

68 in total

1. Multimodality imaging for improved detection of epileptogenic foci in tuberous sclerosis complex.

Authors: E Asano; D C Chugani; O Muzik; C Shen; C Juhász; J Janisse; J Ager; A Canady; J R Shah; A K Shah; C Watson; H T Chugani
Journal: Neurology Date: 2000-05-23 Impact factor: 9.910

2. Serotonin blocks different patterns of low Mg2+-induced epileptiform activity in rat entorhinal cortex, but not hippocampus.

Authors: D Schmitz; R M Empson; T Gloveli; U Heinemann
Journal: Neuroscience Date: 1997-01 Impact factor: 3.590

3. The serotonergic innervation of the cerebral cortex in man and its changes in focal cortical dysplasia.

Authors: S Trottier; B Evrard; J P Vignal; J M Scarabin; P Chauvel
Journal: Epilepsy Res Date: 1996-10 Impact factor: 3.045

4. Reduced serotonin release and serotonin uptake sites in the rat nucleus accumbens and striatum after prenatal cocaine exposure.

Authors: Qing Shan Yan
Journal: Brain Res Date: 2002-03-01 Impact factor: 3.252

5. Altered serotonin and dopamine metabolism in the CNS of serotonin 5-HT(1A) or 5-HT(1B) receptor knockout mice.

Authors: A R Ase; T A Reader; R Hen; M Riad; L Descarries
Journal: J Neurochem Date: 2000-12 Impact factor: 5.372

6. Greater loss of 5-HT(2A) receptors in midlife than in late life.

Authors: Yvette I Sheline; Mark A Mintun; Stephen M Moerlein; Abraham Z Snyder
Journal: Am J Psychiatry Date: 2002-03 Impact factor: 18.112

7. Distribution of 5HT2A receptors in the human brain: comparison of data in vivo and post mortem.

Authors: F Forutan; S Estalji; M Beu; S Nikolaus; K Hamacher; H H Coenen; H Vosberg; H W Müller-Gärtner; R Larisch
Journal: Nuklearmedizin Date: 2002 Impact factor: 1.379

8. Lamotrigine inhibits monoamine uptake in vitro and modulates 5-hydroxytryptamine uptake in rats.

Authors: E Southam; D Kirkby; G A Higgins; R M Hagan
Journal: Eur J Pharmacol Date: 1998-09-25 Impact factor: 4.432

9. Effect of acute administration of various 5-HT receptor agonists on focal hippocampal seizures in freely moving rats.

Authors: K Watanabe; Y Minabe; C R Ashby; H Katsumori
Journal: Eur J Pharmacol Date: 1998-06-05 Impact factor: 4.432

10. Abnormalities in 5-HT1A and 5-HT1B receptor binding in severe-seizure genetically epilepsy-prone rats (GEPR-9s).

Authors: M A Statnick; J W Dailey; P C Jobe; R A Browning
Journal: Neuropharmacology Date: 1996-01 Impact factor: 5.250

19 in total

1. Depressive behavior and selective down-regulation of serotonin receptor expression after early-life seizures: reversal by environmental enrichment.

Authors: Sookyong Koh; Rhamy Magid; Hyokwon Chung; Christy D Stine; Dawn N Wilson
Journal: Epilepsy Behav Date: 2007-02 Impact factor: 2.937

2. In vivo interaction between serotonin and galanin receptors types 1 and 2 in the dorsal raphe: implication for limbic seizures.

Authors: Andrey M Mazarati; Roger A Baldwin; Steve Shinmei; Raman Sankar
Journal: J Neurochem Date: 2005-10-07 Impact factor: 5.372

Does Serotonin Play a Role in Epilepsy?

1. Multimodality imaging for improved detection of epileptogenic foci in tuberous sclerosis complex.

2. Serotonin blocks different patterns of low Mg2+-induced epileptiform activity in rat entorhinal cortex, but not hippocampus.

3. The serotonergic innervation of the cerebral cortex in man and its changes in focal cortical dysplasia.

4. Reduced serotonin release and serotonin uptake sites in the rat nucleus accumbens and striatum after prenatal cocaine exposure.

5. Altered serotonin and dopamine metabolism in the CNS of serotonin 5-HT(1A) or 5-HT(1B) receptor knockout mice.

6. Greater loss of 5-HT(2A) receptors in midlife than in late life.

7. Distribution of 5HT2A receptors in the human brain: comparison of data in vivo and post mortem.

8. Lamotrigine inhibits monoamine uptake in vitro and modulates 5-hydroxytryptamine uptake in rats.

9. Effect of acute administration of various 5-HT receptor agonists on focal hippocampal seizures in freely moving rats.

10. Abnormalities in 5-HT1A and 5-HT1B receptor binding in severe-seizure genetically epilepsy-prone rats (GEPR-9s).

1. Depressive behavior and selective down-regulation of serotonin receptor expression after early-life seizures: reversal by environmental enrichment.

2. In vivo interaction between serotonin and galanin receptors types 1 and 2 in the dorsal raphe: implication for limbic seizures.

Review 3. Update on depression in neurologic illness: stroke, epilepsy, and multiple sclerosis.

Review 4. Physiological bases of the K+ and the glutamate/GABA hypotheses of epilepsy.

5. SLC6A4 gene variants and temporal lobe epilepsy susceptibility: a meta-analysis.

6. 5-HT1A receptor binding in temporal lobe epilepsy patients with and without major depression.

7. Depression after status epilepticus: behavioural and biochemical deficits and effects of fluoxetine.

8. Exploring selective serotonergic modulation involved in the anticonvulsant effect of Ficus religiosa fig extract.

9. High dose of 8-OH-DPAT decreases maximal dentate gyrus activation and facilitates granular cell plasticity in vivo.

Review 10. Drug Treatment of Epilepsy Neuropsychiatric Comorbidities in Children.