Regulation of connective tissue homeostasis in the skin by mechanical forces.

Mechanical forces come in a variety of different forms and act on many more tissues than the obvious vascular and musculo-skeletal systems. Next to soluble mediators, they have caught our attention as potent regulatory parameters in modifying the metabolism and phenotype of cells. This paper concentrates on the response of the skin to tensile forces and describes the adaptive phenotype of fibroblasts residing in the dermal connective tissue. Work from a number of different groups suggests that tension induces in these cells many biological properties which have been found in pathological conditions, e.g. in fibrotic skin lesions. Mechanical tension can therefore be regarded as an additional important regulatory parameter, which we would like to better understand with respect to mechanosensing cellular structures and specific or shared signaling pathways.