Literature DB >> 15343277

Gene-promoter hypermethylation as a biomarker in lung cancer.

Steven A Belinsky1.   

Abstract

Silencing of genes by aberrant promoter hypermethylation is now recognized as a crucial component in cancer initiation and progression. Highly sensitive assays have been developed to assess gene-promoter methylation in biological fluids. The detection of methylated genes in sputum could lead to the development of a screening test to non-invasively identify early cancer in high-risk people.

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Year:  2004        PMID： 15343277     DOI： 10.1038/nrc1432

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  178 in total

1.  Sex-specific association of sequence variants in CBS and MTRR with risk for promoter hypermethylation in the lung epithelium of smokers.

Authors:  Kristina G Flores; Christine A Stidley; Amanda J Mackey; Maria A Picchi; Sally P Stabler; Jill M Siegfried; Tim Byers; Marianne Berwick; Steven A Belinsky; Shuguang Leng
Journal:  Carcinogenesis       Date:  2012-06-04       Impact factor: 4.944

Review 2.  Stress and the epigenetic landscape: a link to the pathobiology of human diseases?

Authors:  Sarah E Johnstone; Stephen B Baylin
Journal:  Nat Rev Genet       Date:  2010-10-05       Impact factor: 53.242

3.  DNA methylation biomarkers for lung cancer.

Authors:  Tibor A Rauch; Zunde Wang; Xiwei Wu; Kemp H Kernstine; Arthur D Riggs; Gerd P Pfeifer
Journal:  Tumour Biol       Date:  2011-12-06

Review 4.  The non-small cell lung cancer immune contexture. A major determinant of tumor characteristics and patient outcome.

Authors:  Romain Remark; Christian Becker; Jorge E Gomez; Diane Damotte; Marie-Caroline Dieu-Nosjean; Catherine Sautès-Fridman; Wolf-Herman Fridman; Charles A Powell; Nasser K Altorki; Miriam Merad; Sacha Gnjatic
Journal:  Am J Respir Crit Care Med       Date:  2015-02-15       Impact factor: 21.405

5.  LncRNA MEG3 downregulation mediated by DNMT3b contributes to nickel malignant transformation of human bronchial epithelial cells via modulating PHLPP1 transcription and HIF-1α translation.

Authors:  C Zhou; C Huang; J Wang; H Huang; J Li; Q Xie; Y Liu; J Zhu; Y Li; D Zhang; Q Zhu; C Huang
Journal:  Oncogene       Date:  2017-03-06       Impact factor: 9.867

6.  MicroRNAs level as an initial screening method for early-stage lung cancer: a bivariate diagnostic random-effects meta-analysis.

Authors:  Wen-Jie He; Wen-Hui Li; Bo Jiang; Yu-Feng Wang; Yao-Xiong Xia; Li Wang
Journal:  Int J Clin Exp Med       Date:  2015-08-15

7.  MUC1 in macrophage: contributions to cigarette smoke-induced lung cancer.

Authors:  Xiuling Xu; Mabel T Padilla; Bilan Li; Alexandria Wells; Kosuke Kato; Carmen Tellez; Steven A Belinsky; Kwang Chul Kim; Yong Lin
Journal:  Cancer Res       Date:  2013-11-26       Impact factor: 12.701

Review 8.  The role of DNA methylation in aging, rejuvenation, and age-related disease.

Authors:  Adiv A Johnson; Kemal Akman; Stuart R G Calimport; Daniel Wuttke; Alexandra Stolzing; João Pedro de Magalhães
Journal:  Rejuvenation Res       Date:  2012-10       Impact factor: 4.663

9.  RFTS-deleted DNMT1 enhances tumorigenicity with focal hypermethylation and global hypomethylation.

Authors:  Bo-Kuan Wu; Szu-Chieh Mei; Charles Brenner
Journal:  Cell Cycle       Date:  2014       Impact factor: 4.534

10.  Disturbance of circadian gene expression in breast cancer.

Authors:  Shou-Jen Kuo; Shou-Tung Chen; Kun-Tu Yeh; Ming-Feng Hou; Ya-Sian Chang; Nicholas C Hsu; Jan-Gowth Chang
Journal:  Virchows Arch       Date:  2009-03-19       Impact factor: 4.064
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