OBJECTIVE: The effectiveness of capecitabine, an oral fluoropyrimidine carbamate, is well documented in previously untreated metastatic colorectal cancer patients (overall response rate: 25%). However, its efficacy in patients with metastatic colorectal cancer refractory to 5-fluorouracil/leucovorin (5-FU/LV) has not been determined. This study was performed to evaluate the efficacy and to identify the side-effects of capecitabine in patients with metastatic colorectal cancer showing progression despite 5-FU/LV-based combination chemotherapy. METHODS: Fifty-one metastatic colorectal cancer patients who showed progressive disease in 5-FU/LV-containing regimens (median: two regimes) were treated with capecitabine 1,250 mg/m(2) twice daily (days 1-14 repeated every 3 weeks). RESULTS: Only one partial response was observed (response rate: 2%). Twenty-seven patients (53%) showed stable disease after two cycles. The median time to disease progression of either a partial response or stable disease was 3.4 months. Hand-foot syndrome was the main toxicity of capecitabine and occurred in 35% of cases (grade 3 or 4 in 6%). The median number of cycles administered was two and the relative dose intensity of capecitabine was 80%. CONCLUSION: The response rate to capecitabine was low in metastatic colorectal cancers that were refractory to 5-FU/LV-containing chemotherapy. However, disease stabilization was seen in a significant number of patients.
OBJECTIVE: The effectiveness of capecitabine, an oral fluoropyrimidine carbamate, is well documented in previously untreated metastatic colorectal cancerpatients (overall response rate: 25%). However, its efficacy in patients with metastatic colorectal cancer refractory to 5-fluorouracil/leucovorin (5-FU/LV) has not been determined. This study was performed to evaluate the efficacy and to identify the side-effects of capecitabine in patients with metastatic colorectal cancer showing progression despite 5-FU/LV-based combination chemotherapy. METHODS: Fifty-one metastatic colorectal cancerpatients who showed progressive disease in 5-FU/LV-containing regimens (median: two regimes) were treated with capecitabine 1,250 mg/m(2) twice daily (days 1-14 repeated every 3 weeks). RESULTS: Only one partial response was observed (response rate: 2%). Twenty-seven patients (53%) showed stable disease after two cycles. The median time to disease progression of either a partial response or stable disease was 3.4 months. Hand-foot syndrome was the main toxicity of capecitabine and occurred in 35% of cases (grade 3 or 4 in 6%). The median number of cycles administered was two and the relative dose intensity of capecitabine was 80%. CONCLUSION: The response rate to capecitabine was low in metastatic colorectal cancers that were refractory to 5-FU/LV-containing chemotherapy. However, disease stabilization was seen in a significant number of patients.
Authors: Thomas J George; Alison M Ivey; Azka Ali; Ji-Hyun Lee; Yu Wang; Karen C Daily; Brian H Ramnaraign; Sanda A Tan; Krista P Terracina; Thomas E Read; Long H Dang; Atif Iqbal Journal: Oncologist Date: 2021-02-22
Authors: H J Kang; H M Chang; T W Kim; M-H Ryu; H J Sohn; J H Yook; S T Oh; B S Kim; J-S Lee; Y-K Kang Journal: Br J Cancer Date: 2005-01-31 Impact factor: 7.640
Authors: J-L Lee; Y-K Kang; H J Kang; K-H Lee; D Y Zang; B-Y Ryoo; J G Kim; S R Park; W K Kang; D B Shin; M-H Ryu; H M Chang; T-W Kim; J H Baek; Y J Min Journal: Br J Cancer Date: 2008-07-29 Impact factor: 7.640
Authors: Umut Disel; Alexis Germain; Bahar Yilmazel; Huseyin Abali; Filiz Aka Bolat; Roman Yelensky; Julia A Elvin; Doron Lipson; Juliann Chmielecki; Kai Wang; Philip J Stephens; Jeffrey S Ross; Vincent A Miller; Siraj M Ali; Thomas J George Journal: Oncoscience Date: 2015-07-01