| Literature DB >> 15341965 |
J R Falck1, Deb K Barma, Suchismita Mohapatra, A Bandyopadhyay, Komandla Malla Reddy, Jianjun Qi, William B Campbell.
Abstract
The four stereoisomers of the endothelial-derived vasorelaxant 11,12,15(S)-trihydroxyeicosatrienoic acid [1, 11,12,15(S)-THETA] were prepared by a triply convergent, asymmetric route that exploited the stereospecific, copper mediated cross-coupling of alpha,beta-dialkoxystannanes with organic electrophiles and the utility of dialkylthionocarbamates as orthogonal alcohol protective groups. Only 11(R),12(S),15(S)-THETA was comparable to natural material by HPLC, GC/MS, and in vitro bioassay.Entities:
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Year: 2004 PMID： 15341965 DOI： 10.1016/j.bmcl.2004.07.019
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823