| Literature DB >> 15341963 |
Jerry M Troutman1, Kareem A H Chehade, Katarzyna Kiegiel, Douglas A Andres, H Peter Spielmann.
Abstract
Three isoprenoid diphosphate analogues of farnesyl diphosphate (FPP) where the diphosphate has been replaced by methylene diphosphonate and the negative charges masked by frangible pivaloyloxymethyl (POM) esters were prepared. Farnesyl methylenediphosphonate is a sub-micromolar substrate for protein farnesyl transferase. The tripivaloyloxymethyl esters of isoprenoid methylenediphosphonate have significantly increased lipophilicity and may act as important farnesyl diphosphate prodrugs.Entities:
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Year: 2004 PMID： 15341963 DOI： 10.1016/j.bmcl.2004.07.017
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823