| Literature DB >> 15341942 |
Andrew J Souers1, Dariusz Wodka, Ju Gao, Jared C Lewis, Anil Vasudevan, Robert Gentles, Sevan Brodjian, Brian Dayton, Christopher A Ogiela, Dennis Fry, Lisa E Hernandez, Kennan C Marsh, Christine A Collins, Philip R Kym.
Abstract
A high-throughput screen was performed in order to identify chemotypes that are bound by the melanin concentrating hormone receptor-1 (MCHr1). A novel 2-amino-8-alkoxyquinoline compound (1) was identified and subsequently optimized using a parallel and automated procedure for the rapid production of multiple analogs. The structure-activity relationships that emerged from this effort are described, along with selected pharmacokinetic parameters of compound (d)-61 when dosed orally in diet-induced obese mice.Entities:
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Year: 2004 PMID： 15341942 DOI： 10.1016/j.bmcl.2004.07.032
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823