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Literature DB >> 15341785

Transporter-mediated drug delivery: recent progress and experimental approaches.

Abstract

A comprehensive list of drug transporters has recently become available as a result of extensive genome analysis, as well as membrane physiology and molecular biology studies. This review covers recent progress in identification and characterization of drug transporters, illustrative cases of successful drug delivery to, or exclusion from, target organs via transporters, and novel experimental approaches to therapeutics using heterologously transduced transporters in tissues. We aim to provide clues that could lead to efficient strategies for the use of transporters to deliver drugs and/or to optimize lead compounds.

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Year: 2004 PMID： 15341785 DOI： 10.1016/S1359-6446(04)03198-8

Source DB: PubMed Journal: Drug Discov Today ISSN： 1359-6446 Impact factor: 7.851

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Cited

16 in total

Review 1. Transport in technicolor: mapping ATP-binding cassette transporters in sea urchin embryos.

Authors: Tufan Gökirmak; Lauren E Shipp; Joseph P Campanale; Sascha C T Nicklisch; Amro Hamdoun
Journal: Mol Reprod Dev Date: 2014-08-22 Impact factor: 2.609

2. Simulations of the nonlinear dose dependence for substrates of influx and efflux transporters in the human intestine.

Authors: Michael B Bolger; Viera Lukacova; Walter S Woltosz
Journal: AAPS J Date: 2009-05-12 Impact factor: 4.009

3. Molecular and functional identification of organic anion transporter isoforms in cultured bovine mammary epithelial cells (BME-UV).

Authors: M M Al-Bataineh; D Van Der Merwe; B D Schultz; R Gehring
Journal: J Vet Pharmacol Ther Date: 2011-05-30 Impact factor: 1.786

8. Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases.

Authors: Douglas B Kell
Journal: BMC Med Genomics Date: 2009-01-08 Impact factor: 3.063

9. Pharmacokinetics of Stereoisomeric Dipeptide Prodrugs of Acyclovir Following Intravenous and Oral Administrations in Rats: A Study Involving In vivo Corneal Uptake of Acyclovir Following Oral Dosing.

Authors: Ravi S Talluri; Ripal Gaudana; Sudharshan Hariharan; Ashim K Mitra
Journal: Ophthalmol Eye Dis Date: 2009-10-21

Review 10. Plasma membrane transporters in modern liver pharmacology.

Authors: Jose J G Marin
Journal: Scientifica (Cairo) Date: 2012-10-14

Transporter-mediated drug delivery: recent progress and experimental approaches.

Review 1. Transport in technicolor: mapping ATP-binding cassette transporters in sea urchin embryos.

2. Simulations of the nonlinear dose dependence for substrates of influx and efflux transporters in the human intestine.

3. Molecular and functional identification of organic anion transporter isoforms in cultured bovine mammary epithelial cells (BME-UV).

4. Mechanism of cellular uptake of a ruthenium polypyridyl complex.

5. Cultured mammary epithelial monolayers (BME-UV) express functional organic anion and cation transporters.

6. Genome-wide assessment of the carriers involved in the cellular uptake of drugs: a model system in yeast.

Review 7. Rational approaches to improving selectivity in drug design.

8. Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases.

9. Pharmacokinetics of Stereoisomeric Dipeptide Prodrugs of Acyclovir Following Intravenous and Oral Administrations in Rats: A Study Involving In vivo Corneal Uptake of Acyclovir Following Oral Dosing.

Review 10. Plasma membrane transporters in modern liver pharmacology.