Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Correlation between cataleptic freezing and prepulse inhibition of the startle reflex in rats.

Literature DB >> 15341220

Correlation between cataleptic freezing and prepulse inhibition of the startle reflex in rats.

N N Barykina¹, T A Alekhina, V F Chugui, O I Petrenko, N K Popova, V G Kolpakov.

Abstract

GC rats, bred for a predisposition to cataleptic freezing, were found to show a significant negative correlation between the duration of freezing and the level of prepulse inhibition of the startle reflex. In addition, a group of GC rats characterized by increased "nervousness" also showed a negative correlation between the duration of freezing and the extent of habituation of the startle reflex. These correlations were not seen in Wistar rats. Since decreases in the level of prepulse inhibition and habituation of the startle reflex are regarded as characteristic of schizophrenia, it is suggested that cataleptic freezing in GC rats might be used as a model of schizophrenic pyschopathology.

Entities: Disease Species

Mesh：

Year: 2004 PMID： 15341220 DOI： 10.1023/b:neab.0000018754.89242.64

Source DB: PubMed Journal: Neurosci Behav Physiol ISSN： 0097-0549

22 in total

1. "Early" and "late" effects of sustained haloperidol on apomorphine- and phencyclidine-induced sensorimotor gating deficits.

Authors: Z A Martinez; J Oostwegel; M A Geyer; G D Ellison; N R Swerdlow
Journal: Neuropsychopharmacology Date: 2000-11 Impact factor: 7.853

2. NCAM-180 knockout mice display increased lateral ventricle size and reduced prepulse inhibition of startle.

Authors: G K Wood; H Tomasiewicz; U Rutishauser; T Magnuson; R Quirion; J Rochford; L K Srivastava
Journal: Neuroreport Date: 1998-02-16 Impact factor: 1.837

3. Reduced cataleptogenic effects of some neuroleptics in rats with lesioned midbrain raphe and treated with p-chlorophenylalanine.

Authors: W Kostowski; W Gumulka; A Cxlonkowski
Journal: Brain Res Date: 1972-12-24 Impact factor: 3.252

4. Symptom correlates of prepulse inhibition deficits in male schizophrenic patients.

Authors: D L Braff; N R Swerdlow; M A Geyer
Journal: Am J Psychiatry Date: 1999-04 Impact factor: 18.112

5. Developmental stress disrupts habituation but spares prepulse inhibition in young rats.

Authors: T L Finamore; R L Port
Journal: Physiol Behav Date: 2000 Jun 1-15

6. Localizing haloperidol effects on sensorimotor gating in a predictive model of antipsychotic potency.

Authors: S Hart; M Zreik; R Carper; N R Swerdlow
Journal: Pharmacol Biochem Behav Date: 1998-09 Impact factor: 3.533

7. Effects of haloperidol and SCH 23390 on acoustic startle and prepulse inhibition under basal and stimulated conditions.

Authors: S B Schwarzkopf; J P Bruno; T Mitra
Journal: Prog Neuropsychopharmacol Biol Psychiatry Date: 1993-11 Impact factor: 5.067

Correlation between cataleptic freezing and prepulse inhibition of the startle reflex in rats.

1. "Early" and "late" effects of sustained haloperidol on apomorphine- and phencyclidine-induced sensorimotor gating deficits.

2. NCAM-180 knockout mice display increased lateral ventricle size and reduced prepulse inhibition of startle.

3. Reduced cataleptogenic effects of some neuroleptics in rats with lesioned midbrain raphe and treated with p-chlorophenylalanine.

4. Symptom correlates of prepulse inhibition deficits in male schizophrenic patients.

5. Developmental stress disrupts habituation but spares prepulse inhibition in young rats.

6. Localizing haloperidol effects on sensorimotor gating in a predictive model of antipsychotic potency.

7. Effects of haloperidol and SCH 23390 on acoustic startle and prepulse inhibition under basal and stimulated conditions.

8. Impaired startle prepulse inhibition and habituation in patients with schizotypal personality disorder.

9. Clozapine and haloperidol in an animal model of sensorimotor gating deficits in schizophrenia.

10. Glucocorticoids attenuate haloperidol-induced catalepsy through adrenal catecholamines.

1. Improvement of Memory by Means of Ultra-Low Doses of Antibodies to S-100B Antigen.