| Literature DB >> 15341218 |
N G Levitskaya1, E A Sebentsova, L A Andreeva, L Yu Alfeeva, A A Kamenskii, N F Myasoedov.
Abstract
This report describes studies cf the effects of the ACTH(4-10) analog Semax (MEHFPGP) on the behavior of white rats with lesions to the brain dopaminergic system induced by the neurotoxin MPTP. Neurotoxin was given as single i.p. doses of 25 mg/kg. Neurotoxin injections were shown to decrease movement activity and increase anxiety in the animals. Daily intranasal administration of Semax at a dose of 0.2 mg/kg decreased the severity of MPTP-induced behavioral disturbances. The protective activity of Semax in MPTP-induced lesions of the brain dopaminergic system may be associated with both its modulating effect on the dopaminergic system and the neurotrophic action of the peptide.Entities:
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Year: 2004 PMID： 15341218 DOI： 10.1023/b:neab.0000018752.59465.28
Source DB: PubMed Journal: Neurosci Behav Physiol ISSN： 0097-0549