Literature DB >> 1534063

Polymorphism in the RD (D6S45) gene.

P C White1, J Vitek, R G Lahita, P W Speiser.   

Abstract

The RD (D6S45) gene in the class III region of the HLA major histocompatibility complex encodes a protein normally containing 24 consecutive basic-acidic dipeptide repeats. We determined the frequency of variations in the number of repeats by use of the polymerase chain reaction. Of 107 subjects 7 (3.3%) carried genes encoding 22 or 23 repeats. There was no difference in the frequency of such polymorphisms between normal individuals and those with systemic lupus erythematosus, a disease associated with other polymorphisms in the class III region of HLA. The frequency of polymorphisms in proteins with oligopeptide repeats may provide useful information concerning functional constraints on repeat number.

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Year:  1992        PMID： 1534063     DOI： 10.1007/bf00217132

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  13 in total

1.  Human genetics. Bone disease cracks genetics.

Authors:  B Sykes
Journal:  Nature       Date:  1990-11-01       Impact factor: 49.962

2.  The NUP1 gene encodes an essential component of the yeast nuclear pore complex.

Authors:  L I Davis; G R Fink
Journal:  Cell       Date:  1990-06-15       Impact factor: 41.582

3.  The human U1-70K snRNP protein: cDNA cloning, chromosomal localization, expression, alternative splicing and RNA-binding.

Authors:  R A Spritz; K Strunk; C S Surowy; S O Hoch; D E Barton; U Francke
Journal:  Nucleic Acids Res       Date:  1987-12-23       Impact factor: 16.971

4.  Interferons as gene activators. Indications for repeated gene duplication during the evolution of a cluster of interferon-activatable genes on murine chromosome 1.

Authors:  D Choubey; J Snoddy; V Chaturvedi; E Toniato; G Opdenakker; A Thakur; H Samanta; D A Engel; P Lengyel
Journal:  J Biol Chem       Date:  1989-10-15       Impact factor: 5.157

5.  The human RD protein is closely related to nuclear RNA-binding proteins and has been highly conserved.

Authors:  C S Surowy; G Hoganson; J Gosink; K Strunk; R A Spritz
Journal:  Gene       Date:  1990-06-15       Impact factor: 3.688

6.  Generation of single-stranded DNA by the polymerase chain reaction and its application to direct sequencing of the HLA-DQA locus.

Authors:  U B Gyllensten; H A Erlich
Journal:  Proc Natl Acad Sci U S A       Date:  1988-10       Impact factor: 11.205

7.  Genetic analysis of the repetitive carboxyl-terminal domain of the largest subunit of mouse RNA polymerase II.

Authors:  M S Bartolomei; N F Halden; C R Cullen; J L Corden
Journal:  Mol Cell Biol       Date:  1988-01       Impact factor: 4.272

8.  Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction.

Authors:  J L Weber; P E May
Journal:  Am J Hum Genet       Date:  1989-03       Impact factor: 11.025

9.  Family study of the major histocompatibility complex in patients with systemic lupus erythematosus: importance of null alleles of C4A and C4B in determining disease susceptibility.

Authors:  A H Fielder; M J Walport; J R Batchelor; R I Rynes; C M Black; I A Dodi; G R Hughes
Journal:  Br Med J (Clin Res Ed)       Date:  1983-02-05

10.  The human mid-size neurofilament subunit: a repeated protein sequence and the relationship of its gene to the intermediate filament gene family.

Authors:  M W Myers; R A Lazzarini; V M Lee; W W Schlaepfer; D L Nelson
Journal:  EMBO J       Date:  1987-06       Impact factor: 11.598
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  1 in total

1.  cDNA cloning and characterization of the protein encoded by RD, a gene located in the class III region of the human major histocompatibility complex.

Authors:  J Cheng; K J Macon; J E Volanakis
Journal:  Biochem J       Date:  1993-09-01       Impact factor: 3.857
  1 in total

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