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Literature DB >> 15340383

Metabolite profiling: from diagnostics to systems biology.

Alisdair R Fernie¹, Richard N Trethewey, Arno J Krotzky, Lothar Willmitzer.

Abstract

The concept of metabolite profiling has been around for several decades, but only recent technical innovations have allowed metabolite profiling to be carried out on a large scale - with respect to both the number of metabolites measured and the number of experiments carried out. As a result, the power of metabolite profiling as a technology platform for diagnostics, and the research areas of gene-function analysis and systems biology, is now beginning to be fully realized.

Mesh：

Substances：
Proteins

Year: 2004 PMID： 15340383 DOI： 10.1038/nrm1451

Source DB: PubMed Journal: Nat Rev Mol Cell Biol ISSN： 1471-0072 Impact factor: 94.444

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Cited

222 in total

1. Use of optimized 1D TOCSY NMR for improved quantitation and metabolomic analysis of biofluids.

Authors: Peter Sandusky; Emmanuel Appiah-Amponsah; Daniel Raftery
Journal: J Biomol NMR Date: 2011-03-10 Impact factor: 2.835

Review 2. Stable isotope-resolved metabolomics and applications for drug development.

Authors: Teresa W-M Fan; Pawel K Lorkiewicz; Katherine Sellers; Hunter N B Moseley; Richard M Higashi; Andrew N Lane
Journal: Pharmacol Ther Date: 2011-12-23 Impact factor: 12.310

3. On the discordance of metabolomics with proteomics and transcriptomics: coping with increasing complexity in logic, chemistry, and network interactions scientific correspondence.

Authors: Alisdair R Fernie; Mark Stitt
Journal: Plant Physiol Date: 2012-01-17 Impact factor: 8.340

4. One-step acquisition of functional biomolecules from tissues.

Authors: Sumit Paliwal; Makoto Ogura; Samir Mitragotri
Journal: Proc Natl Acad Sci U S A Date: 2010-08-02 Impact factor: 11.205

5. Combining genetic diversity, informatics and metabolomics to facilitate annotation of plant gene function.

Authors: Takayuki Tohge; Alisdair R Fernie
Journal: Nat Protoc Date: 2010-06-10 Impact factor: 13.491

6. PyMS: a Python toolkit for processing of gas chromatography-mass spectrometry (GC-MS) data. Application and comparative study of selected tools.

Authors: Sean O'Callaghan; David P De Souza; Andrew Isaac; Qiao Wang; Luke Hodkinson; Moshe Olshansky; Tim Erwin; Bill Appelbe; Dedreia L Tull; Ute Roessner; Antony Bacic; Malcolm J McConville; Vladimir A Likić
Journal: BMC Bioinformatics Date: 2012-05-30 Impact factor: 3.169

Metabolite profiling: from diagnostics to systems biology.

1. Use of optimized 1D TOCSY NMR for improved quantitation and metabolomic analysis of biofluids.

Review 2. Stable isotope-resolved metabolomics and applications for drug development.

3. On the discordance of metabolomics with proteomics and transcriptomics: coping with increasing complexity in logic, chemistry, and network interactions scientific correspondence.

4. One-step acquisition of functional biomolecules from tissues.

5. Combining genetic diversity, informatics and metabolomics to facilitate annotation of plant gene function.

6. PyMS: a Python toolkit for processing of gas chromatography-mass spectrometry (GC-MS) data. Application and comparative study of selected tools.

7. Integrative Approaches to Enhance Understanding of Plant Metabolic Pathway Structure and Regulation.

8. Molecular Formula Identification Using Isotope Pattern Analysis and Calculation of Fragmentation Trees.

Review 9. New insights into the metabolism of aspartate-family amino acids in plant seeds.

Review 10. Targeted lipidomic strategies for oxygenated metabolites of polyunsaturated fatty acids.