Literature DB >> 15340204

Synthesis of the epimer of pericosine B from (-)-quinic Acid.

Yoshihide Usami1, Chikage Hatsuno, Hiroe Yamamoto, Manabu Tanabe, Atsushi Numata.   

Abstract

Synthesis of the epimer of pericosine B from (-)-quinic acid was achieved. This synthesis involves some regioselective and stereoselective processes. The desired product showed lower cytotoxic activity in comparison with natural pericosine B against the P388 leukemia cell line. The result implies that the stereocenter of C-6 in natural pericosine B plays an important role in this activity.

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Year:  2004        PMID： 15340204     DOI： 10.1248/cpb.52.1130

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  3 in total

Review 1.  Can Some Marine-Derived Fungal Metabolites Become Actual Anticancer Agents?

Authors:  Nelson G M Gomes; Florence Lefranc; Anake Kijjoa; Robert Kiss
Journal:  Mar Drugs       Date:  2015-06-19       Impact factor: 5.118

2.  Synthesis of Natural O-Linked Carba-Disaccharides, (+)- and (-)-Pericosine E, and Their Analogues as α-Glucosidase Inhibitors.

Authors:  Yoshihide Usami; Koji Mizuki; Rikiya Kawahata; Makio Shibano; Atsuko Sekine; Hiroki Yoneyama; Shinya Harusawa
Journal:  Mar Drugs       Date:  2017-01-23       Impact factor: 5.118

3.  Synthetic efforts for stereo structure determination of cytotoxic marine natural product pericosines as metabolites of Periconia sp. from sea hare.

Authors:  Yoshihide Usami; Hayato Ichikawa; Masao Arimoto
Journal:  Int J Mol Sci       Date:  2008-03-24       Impact factor: 6.208
  3 in total

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