Literature DB >> 15340195

Novel antiviral fucoidan from sporophyll of Undaria pinnatifida (Mekabu).

Jung-Bum Lee1, Kyoko Hayashi, Minoru Hashimoto, Takahisa Nakano, Toshimitsu Hayashi.   

Abstract

Structural characterization and antiviral activities of fucoidan from sporophyll of Undaria pinnatifida (Mekabu) was examined. The fucoidan was composed of fucose and galactose with an approximately ratio of 1.0:1.1. Degree of substitution of sulfate was 0.72 and its apparent molecular weight was 9,000. Methylation analyses showed that fucoidan had various sugar linkages, and revealed that the fucoidan might have complicated structure. This fucoidan showed potent antiviral activities against herpes simplex virus type 1 (HSV-1), HSV-2, and human cytomegalovirus.

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Year:  2004        PMID： 15340195     DOI： 10.1248/cpb.52.1091

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  43 in total

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