Literature DB >> 15339659

The lingering enigma of the allelic exclusion mechanism.

Raul Mostoslavsky1, Frederick W Alt, Klaus Rajewsky.   

Abstract

B lymphocytes produce diverse antibody specificities by "randomly" assembling antibody genes from germline segments. Yet, though each B lymphocyte has multiple allelic loci for the different antibody chains, each clonally derived mature B lymphocyte expresses a single species of antibody with a unique specificity via a process termed allelic exclusion. Despite some progress, the precise mechanism of allelic exclusion remains an enigma.

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Year:  2004        PMID： 15339659     DOI： 10.1016/j.cell.2004.08.023

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  61 in total

1.  Regulation of TCRβ allelic exclusion by gene segment proximity and accessibility.

Authors:  Hrisavgi D Kondilis-Mangum; Han-Yu Shih; Grace Mahowald; Barry P Sleckman; Michael S Krangel
Journal:  J Immunol       Date:  2011-11-11       Impact factor: 5.422

2.  Telomeric IGH losses detectable by fluorescence in situ hybridization in chronic lymphocytic leukemia reflect somatic VH recombination events.

Authors:  Iwona Wlodarska; Christine Matthews; Ellen Veyt; Helena Pospisilova; Mark A Catherwood; Tim S Poulsen; Vera Vanhentenrijk; Rachel Ibbotson; Peter Vandenberghe; T C M Curly Morris; H Denis Alexander
Journal:  J Mol Diagn       Date:  2007-02       Impact factor: 5.568

3.  Productive coupling of accessible Vbeta14 segments and DJbeta complexes determines the frequency of Vbeta14 rearrangement.

Authors:  Sheila Ranganath; Andrea C Carpenter; Megan Gleason; Albert C Shaw; Craig H Bassing; Frederick W Alt
Journal:  J Immunol       Date:  2008-02-15       Impact factor: 5.422

4.  Equal transcription rates of productively and nonproductively rearranged immunoglobulin mu heavy chain alleles in a pro-B cell line.

Authors:  Andrea B Eberle; Kai Herrmann; Hans-Martin Jäck; Oliver Mühlemann
Journal:  RNA       Date:  2009-04-10       Impact factor: 4.942

5.  Initiation of allelic exclusion by stochastic interaction of Tcrb alleles with repressive nuclear compartments.

Authors:  Ryan J Schlimgen; Karen L Reddy; Harinder Singh; Michael S Krangel
Journal:  Nat Immunol       Date:  2008-06-08       Impact factor: 25.606

6.  Biallelic, ubiquitous transcription from the distal germline Ig{kappa} locus promoter during B cell development.

Authors:  Rupesh H Amin; Dragana Cado; Hector Nolla; Dan Huang; Susan A Shinton; Yan Zhou; Richard R Hardy; Mark S Schlissel
Journal:  Proc Natl Acad Sci U S A       Date:  2008-12-30       Impact factor: 11.205

Review 7.  Genome Topology Control of Antigen Receptor Gene Assembly.

Authors:  Brittney M Allyn; Kyutae D Lee; Craig H Bassing
Journal:  J Immunol       Date:  2020-05-15       Impact factor: 5.422

Review 8.  Epigenetic aspects of lymphocyte antigen receptor gene rearrangement or 'when stochasticity completes randomness'.

Authors:  Sébastien Jaeger; Bastien Fernandez; Pierre Ferrier
Journal:  Immunology       Date:  2013-06       Impact factor: 7.397

Review 9.  Hematopoietic stem cells for cancer immunotherapy.

Authors:  Eric Gschweng; Satiro De Oliveira; Donald B Kohn
Journal:  Immunol Rev       Date:  2014-01       Impact factor: 12.988

10.  Epigenetic regulation of antigen receptor gene rearrangement.

Authors:  Salvatore Spicuglia; Joaquin Zacarias-Cabeza; Aleksandra Pekowska; Pierre Ferrier
Journal:  F1000 Biol Rep       Date:  2010-03-25
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