Literature DB >> 15339638

Food for thought: essential fatty acid protects against neuronal deficits in transgenic mouse model of AD.

Lennart Mucke1, Robert E Pitas.   

Abstract

Interactions between environmental and genetic factors may contribute to neurodegenerative disease. In this issue of Neuron, Calon et al. report that a diet low in an essential omega-3 polyunsaturated fatty acid (docosahexaenoic acid) depletes postsynaptic proteins and exacerbates behavioral alterations in a transgenic mouse model of Alzheimer's disease.

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Year:  2004        PMID： 15339638     DOI： 10.1016/j.neuron.2004.08.025

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  2 in total

1.  The increase of choline acetyltransferase activity by docosahexaenoic acid in NG108-15 cells grown in serum-free medium is independent of its effect on cell growth.

Authors:  Eva Machová; Barbora Málková; Vera Lisá; Jana Nováková; Vladimír Dolezal
Journal:  Neurochem Res       Date:  2006-10       Impact factor: 3.996

Review 2.  EFAD transgenic mice as a human APOE relevant preclinical model of Alzheimer's disease.

Authors:  Leon M Tai; Deebika Balu; Evangelina Avila-Munoz; Laila Abdullah; Riya Thomas; Nicole Collins; Ana Carolina Valencia-Olvera; Mary Jo LaDu
Journal:  J Lipid Res       Date:  2017-04-07       Impact factor: 5.922
  2 in total

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