Xue-Wu Zhang1, Quan Sun, Ming Jin, Chun-Mei Piao, Lian-Hua Li. 1. Department of Biochemistry & Molecular Biology, College of Medicine, Yanbian University, Yanji, Jilin Province 133000, China. zlz2913835@sina.com
Abstract
OBJECTIVE: To study the effect of Sorbaria Sorbifolia extract on anti-oxidative activities in rats with precancerosis induced by diethylnitrosamine. METHODS: Sorbaria sorbifolia was perfused into stomach of rats with DEN-induced precancerosis, then the biochemical indexes were investigated. The activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), and the concentrations of malondialdehyde (MDA), glutathione (GSH) were investigated by colorimetric method. RESULTS: Sorbaria sorbifolia extract increased SOD, GSH-PX and decreased MDA, GSH levels in serum and liver homogenate. CONCLUSION: Sorbaria Sorbifolia extract significantly increased anti-oxidative activities in rats with precancerosis induced by diethylnitrosamine.
OBJECTIVE: To study the effect of Sorbaria Sorbifolia extract on anti-oxidative activities in rats with precancerosis induced by diethylnitrosamine. METHODS:Sorbaria sorbifolia was perfused into stomach of rats with DEN-induced precancerosis, then the biochemical indexes were investigated. The activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), and the concentrations of malondialdehyde (MDA), glutathione (GSH) were investigated by colorimetric method. RESULTS:Sorbaria sorbifolia extract increased SOD, GSH-PX and decreased MDA, GSH levels in serum and liver homogenate. CONCLUSION:Sorbaria Sorbifolia extract significantly increased anti-oxidative activities in rats with precancerosis induced by diethylnitrosamine.