Literature DB >> 1533776

Epidemiology, etiology, diagnostic evaluation, and treatment of low back pain.

D Borenstein1.   

Abstract

New data concerning the epidemiology, etiology, diagnostic evaluation, and treatment of low back pain have been reported over the past year. Low back pain remains an expensive health problem for our country costing an estimated 24 billion dollars in direct medical expenses. The degeneration of intervertebral disks may be associated with the appearance of increased amounts of specific collagen types that are not present in normal disk specimens. In an important study of monozygotic twins, smoking was identified as an independent variable associated with advanced degeneration of intervertebral disks. Sacral insufficiency fractures are a significant cause of back pain particularly in elderly individuals with predisposing disorders and medications. Radiographic techniques continue to improve and offer earlier detection of the anatomic abnormalities associated with clinical disorders including inflammatory myelitis. Epidural corticosteroid injections are helpful for decreasing symptoms of radiculopathy, but the injections may only be placed in the correct location in the epidural space 50% of the time unless corroborated by radiographic techniques. Chiropractors suggest that manipulation therapy is cost effective for treatment of low back pain in comparison with therapies given by physicians.

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Year:  1992        PMID: 1533776     DOI: 10.1097/00002281-199204000-00016

Source DB:  PubMed          Journal:  Curr Opin Rheumatol        ISSN: 1040-8711            Impact factor:   5.006


  6 in total

1.  Accelerated aging of intervertebral discs in a mouse model of progeria.

Authors:  Nam Vo; Hyoung-Yeon Seo; Andria Robinson; Gwendolyn Sowa; Douglas Bentley; Lauren Taylor; Rebecca Studer; Arvydas Usas; Johnny Huard; Sean Alber; Simon C Watkins; Joon Lee; Paulo Coehlo; Dong Wang; Mattia Loppini; Paul D Robbins; Laura J Niedernhofer; James Kang
Journal:  J Orthop Res       Date:  2010-12       Impact factor: 3.494

2.  Downregulation of microRNA-193a-3p is involved in invertebral disc degeneration by targeting MMP14.

Authors:  Ming-Liang Ji; Xue-Jun Zhang; Pei-Liang Shi; Jun Lu; Shan-Zheng Wang; Qing Chang; Hui Chen; Chen Wang
Journal:  J Mol Med (Berl)       Date:  2015-12-01       Impact factor: 4.599

3.  Investigating the role of DNA damage in tobacco smoking-induced spine degeneration.

Authors:  Luigi A Nasto; Kevin Ngo; Adriana S Leme; Andria R Robinson; Qing Dong; Peter Roughley; Arvydas Usas; Gwendolyn A Sowa; Enrico Pola; James Kang; Laura J Niedernhofer; Steven Shapiro; Nam V Vo
Journal:  Spine J       Date:  2013-11-06       Impact factor: 4.166

4.  Potential use of Sox9 gene therapy for intervertebral degenerative disc disease.

Authors:  Ronjon Paul; Rex C Haydon; Hongwei Cheng; Akira Ishikawa; Nikola Nenadovich; Wei Jiang; Lan Zhou; Benjamin Breyer; Tao Feng; Purnendu Gupta; Tong-Chuan He; Frank M Phillips
Journal:  Spine (Phila Pa 1976)       Date:  2003-04-15       Impact factor: 3.468

5.  Influences of circulatory factors on intervertebral disc aging phenotype.

Authors:  Changbin Lei; Debora Colangelo; Prashanti Patil; Vivian Li; Kevin Ngo; Dong Wang; Qing Dong; Matthew J Yousefzadeh; Hongsheng Lin; Joon Lee; James Kang; Gwendolyn Sowa; Tony Wyss-Coray; Laura J Niedernhofer; Paul D Robbins; Derek M Huffman; Nam Vo
Journal:  Aging (Albany NY)       Date:  2020-06-11       Impact factor: 5.682

6.  Leptin regulates disc cartilage endplate degeneration and ossification through activation of the MAPK-ERK signalling pathway in vivo and in vitro.

Authors:  Ying-Chao Han; Bin Ma; Song Guo; Mingjie Yang; Li-Jun Li; Shan-Jin Wang; Jun Tan
Journal:  J Cell Mol Med       Date:  2018-01-26       Impact factor: 5.310

  6 in total

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