Literature DB >> 15337528

c-Cbl binds to tyrosine-phosphorylated neurotrophin receptor p75 and induces its ubiquitination.

Thomas Ohrt1, Annalisa Mancini, Teruko Tamura, Rainer Niedenthal.   

Abstract

The p75 neurotrophin receptor (p75NTR) has dual functions in cell survival and cell death but its intracellular signalling pathways are not understood. Here we describe that in rat brain and in pervanadate-stimulated PCNA and HEK293 cells p75NTR is phosphorylated at a single tyrosine residue within the cytosolic C-terminus. Phosphorylated tyrosine 308 constitutes a binding site for the ubiquitin ligase c-Cbl. This interaction is a prerequisite for ubiquitination of p75NTR. Our data suggest a c-Cbl-dependent ubiquitination of p75NTR involved in the regulation of p75NTR signalling.

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Year:  2004        PMID： 15337528     DOI： 10.1016/j.cellsig.2004.03.017

Source DB:  PubMed          Journal:  Cell Signal        ISSN： 0898-6568            Impact factor:   4.315


  11 in total

1.  p75 neurotrophin receptor reduces ligand-induced Trk receptor ubiquitination and delays Trk receptor internalization and degradation.

Authors:  Joe P S Makkerh; Claire Ceni; Daniel S Auld; François Vaillancourt; Genevieve Dorval; Philip A Barker
Journal:  EMBO Rep       Date:  2005-10       Impact factor: 8.807

2.  Fates of neurotrophins after retrograde axonal transport: phosphorylation of p75NTR is a sorting signal for delayed degradation.

Authors:  Rafal Butowt; Christopher S von Bartheld
Journal:  J Neurosci       Date:  2009-08-26       Impact factor: 6.167

Review 3.  c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses.

Authors:  Christine B F Thien; Wallace Y Langdon
Journal:  Biochem J       Date:  2005-10-15       Impact factor: 3.857

4.  Direct binding of Cbl to Tyr568 and Tyr936 of the stem cell factor receptor/c-Kit is required for ligand-induced ubiquitination, internalization and degradation.

Authors:  Kristina Masson; Elke Heiss; Hamid Band; Lars Rönnstrand
Journal:  Biochem J       Date:  2006-10-01       Impact factor: 3.857

5.  Role of tyrosine phosphorylation in the antioxidant effects of the p75 neurotrophin receptor.

Authors:  Tong Zhang; Zhiping Mi; Nina F Schor
Journal:  Oxid Med Cell Longev       Date:  2009 Sep-Oct       Impact factor: 6.543

Review 6.  Tracking TrkA's trafficking: NGF receptor trafficking controls NGF receptor signaling.

Authors:  T Moises; A Dreier; S Flohr; M Esser; E Brauers; K Reiss; D Merken; J Weis; A Krüttgen
Journal:  Mol Neurobiol       Date:  2007-04       Impact factor: 5.590

Review 7.  PTPL1: a large phosphatase with a split personality.

Authors:  Ogan D Abaan; Jeffrey A Toretsky
Journal:  Cancer Metastasis Rev       Date:  2008-06       Impact factor: 9.264

8.  Nerve growth factor stimulates the concentration of TrkA within lipid rafts and extracellular signal-regulated kinase activation through c-Cbl-associated protein.

Authors:  Allison S Limpert; J Colleen Karlo; Gary E Landreth
Journal:  Mol Cell Biol       Date:  2007-06-04       Impact factor: 4.272

9.  Disparate Regulatory Mechanisms Control Fat3 and P75NTR Protein Transport through a Conserved Kif5-Interaction Domain.

Authors:  Haixia Cheng; Jessica Burroughs-Garcia; Jacqueline E Birkness; Jonathan C Trinidad; Michael R Deans
Journal:  PLoS One       Date:  2016-10-27       Impact factor: 3.240

Review 10.  In vivo functions of p75NTR: challenges and opportunities for an emerging therapeutic target.

Authors:  Subash C Malik; Elif G Sozmen; Bernat Baeza-Raja; Natacha Le Moan; Katerina Akassoglou; Christian Schachtrup
Journal:  Trends Pharmacol Sci       Date:  2021-07-29       Impact factor: 17.638
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