| Literature DB >> 15337433 |
Alessandra Ammazzalorso1, Rosa Amoroso, Giancarlo Bettoni, Marialuigia Fantacuzzi, Barbara De Filippis, Letizia Giampietro, Cristina Maccallini, Domenico Paludi, Maria L Tricca.
Abstract
Compounds structurally related to the known antimicrobial drug linezolid were selected in order to evaluate the influence of electron-withdrawing properties and altered geometric features as a result of the N-substituent modification. After a preliminary study of molecular modeling, cinnamoyl-, pyridin- and pyrimidinoxazolidin-2-ones were synthesized. None of the new compounds showed antibacterial activity.Entities:
Mesh：
Substances：
Year: 2004 PMID： 15337433 DOI： 10.1016/j.farmac.2004.05.002
Source DB: PubMed Journal: Farmaco ISSN： 0014-827X