Literature DB >> 15337322

Expression of proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1beta in the brain during experimental group B streptococcal meningitis.

Young S Kim1, Jari Honkaniemi, Frank R Sharp, Martin G Täuber.   

Abstract

We performed mRNA in situ hybridization for TNF-alpha and IL-1beta from infant rats with group B streptococcal meningitis. Induction of both cytokines was seen in the ependyma and the meninges at 4 h. Both cytokines were expressed in the brain parenchyma at 12 h. Induction of IL-1beta mRNA was seen in vessels within the brain cortex. Neutrophilic infiltrate at all time points examined was minimal and could not account for the observed cytokine expression.

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Year:  2004        PMID: 15337322     DOI: 10.1016/j.molbrainres.2004.06.009

Source DB:  PubMed          Journal:  Brain Res Mol Brain Res        ISSN: 0169-328X


  2 in total

1.  TLR7 and TLR9 trigger distinct neuroinflammatory responses in the CNS.

Authors:  Niranjan B Butchi; Tyson Woods; Min Du; Timothy W Morgan; Karin E Peterson
Journal:  Am J Pathol       Date:  2011-06-14       Impact factor: 4.307

2.  Angiotensin II AT1 receptor blockade ameliorates brain inflammation.

Authors:  Julius Benicky; Enrique Sánchez-Lemus; Masaru Honda; Tao Pang; Martina Orecna; Juan Wang; Yan Leng; De-Maw Chuang; Juan M Saavedra
Journal:  Neuropsychopharmacology       Date:  2010-12-08       Impact factor: 7.853

  2 in total

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