| Literature DB >> 15337321 |
Masanobu Yoshikawa1, Tomomi Kobayashi, Tetsuo Oka, Mitsuru Kawaguchi, Atsushi Hashimoto.
Abstract
We have used real-time quantitative PCR methods to evaluate the effect of the systemic administration of (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801; 0.4 mg/kg) on the gene expression of serine racemase in several brain areas of the rat. The levels of serine racemase mRNA in all the brain areas transiently increased after the administration. The present findings suggest that there is a link between the expression of serine racemase mRNA and the activity of the NMDA receptors.Entities:
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Year: 2004 PMID： 15337321 DOI： 10.1016/j.molbrainres.2004.06.015
Source DB: PubMed Journal: Brain Res Mol Brain Res ISSN： 0169-328X