Literature DB >> 15337269

The intensity dependence of the auditory evoked N1 component as a predictor of response to Citalopram treatment in patients with major depression.

Thomas Linka1, Bernhard W Müller, Stefan Bender, Gudrun Sartory.   

Abstract

The intensity dependence of the auditory evoked N1 ERP component (IDAP) has been suggested as an indicator of central serotonergic neurotransmission with relevance to pharmacological treatment. We report the results of a study evaluating the IDAP in 16 in-patients fulfilling DSM-IV criteria for major depressive episode in the course of treatment with the SSRI Citalopram. Our data revealed a significant correlation between the intensity slopes of the N1 amplitude prior to Citalopram treatment and treatment response: patients with higher intensity slopes of N1 amplitude showed a significantly stronger decrease of HDRS-Score after Citalopram treatment than patients within the lower intensity slope ranges. Our results indicate an association of N1 amplitude intensity dependence with response to antidepressant treatment with Citalopram.

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Year:  2004        PMID： 15337269     DOI： 10.1016/j.neulet.2004.06.038

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  17 in total

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