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Literature DB >> 15337122

Caspases, IAPs and Smac/DIABLO: mechanisms from structural biology.

Abstract

Caspases are the central component of the apoptotic machinery that irreversibly commits a cell to die. Whereas all caspases are structurally similar, those involved in apoptosis can be categorized functionally as either initiator or effector caspases, which are activated by distinct mechanisms. The activated caspases are subject to inhibition by the inhibitor of apoptosis family of proteins. This inhibition can be removed by Smac/DIABLO during apoptosis. The underlying molecular mechanisms of caspase regulation are discussed in this article.

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Year: 2004 PMID： 15337122 DOI： 10.1016/j.tibs.2004.07.003

Source DB: PubMed Journal: Trends Biochem Sci ISSN： 0968-0004 Impact factor: 13.807

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Cited

67 in total

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2. ARTS and Siah collaborate in a pathway for XIAP degradation.

Authors: Jason B Garrison; Ricardo G Correa; Motti Gerlic; Kenneth W Yip; Andreas Krieg; Craig M Tamble; Ranxin Shi; Kate Welsh; Srinivas Duggineni; Ziwei Huang; Keqin Ren; Chunying Du; John C Reed
Journal: Mol Cell Date: 2010-12-23 Impact factor: 17.970

3. Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP.

Authors: Haiying Sun; Zaneta Nikolovska-Coleska; Jianfeng Lu; Jennifer L Meagher; Chao-Yie Yang; Su Qiu; York Tomita; Yumi Ueda; Sheng Jiang; Krzysztof Krajewski; Peter P Roller; Jeanne A Stuckey; Shaomeng Wang
Journal: J Am Chem Soc Date: 2007-11-14 Impact factor: 15.419

4. Iberin induces cell cycle arrest and apoptosis in human neuroblastoma cells.

Authors: Unmesh Jadhav; Ravesanker Ezhilarasan; Steven F Vaughn; Mark A Berhow; Sanjeeva Mohanam
Journal: Int J Mol Med Date: 2007-03 Impact factor: 4.101

Review 5. IAPs: what's in a name?

Authors: Srinivasa M Srinivasula; Jonathan D Ashwell
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10. A New Role for the Mitochondrial Pro-apoptotic Protein SMAC/Diablo in Phospholipid Synthesis Associated with Tumorigenesis.

Authors: Avijit Paul; Yakov Krelin; Tasleem Arif; Rina Jeger; Varda Shoshan-Barmatz
Journal: Mol Ther Date: 2017-12-24 Impact factor: 11.454

Caspases, IAPs and Smac/DIABLO: mechanisms from structural biology.

Review 1. Immunological basis in the pathogenesis and treatment of bladder cancer.

2. ARTS and Siah collaborate in a pathway for XIAP degradation.

3. Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP.

4. Iberin induces cell cycle arrest and apoptosis in human neuroblastoma cells.

Review 5. IAPs: what's in a name?

6. A dp53/JNK-dependant feedback amplification loop is essential for the apoptotic response to stress in Drosophila.

Review 7. Reawakening the cellular death program in neoplasia through the therapeutic blockade of IAP function.

8. Smac deficiency affects endoplasmic reticulum stress-induced apoptosis in human colon cancer cells.

9. Lipid-conjugated Smac analogues.

10. A New Role for the Mitochondrial Pro-apoptotic Protein SMAC/Diablo in Phospholipid Synthesis Associated with Tumorigenesis.