| Literature DB >> 15337117 |
Jörg Martin1, Markus Gruber, Andrei N Lupas.
Abstract
Coiled coils are versatile structural modules that engage in a variety of cellular activities. Recent studies illuminate their role as substrate-binding elements in the chaperone cofactor prefoldin and in the AAA+ ATPases involved in protein (un)folding processes. The use of coiled coils to mediate the binding of non-native proteins represents a novel strategy in chaperone design and a new function for coiled coils.Mesh:
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Year: 2004 PMID: 15337117 DOI: 10.1016/j.tibs.2004.07.004
Source DB: PubMed Journal: Trends Biochem Sci ISSN: 0968-0004 Impact factor: 13.807