| Literature DB >> 15336968 |
Ludwig Missiaen1, Luc Raeymaekers, Leonard Dode, Jo Vanoevelen, Kurt Van Baelen, Jan B Parys, Geert Callewaert, Humbert De Smedt, Siegfried Segaert, Frank Wuytack.
Abstract
Both the endoplasmic reticulum and the Golgi apparatus are agonist-sensitive intracellular Ca2+ stores. The Golgi apparatus has Ca2+-release channels and a Ca2+-uptake mechanism consisting of sarco(endo)plasmic-reticulum Ca2+-ATPases (SERCA) and secretory-pathway Ca2+-ATPases (SPCA). SPCA1 has been shown to transport both Ca2+ and Mn2+ in the Golgi lumen and therefore plays an important role in the cytosolic and intra-Golgi Ca2+ and Mn2+ homeostasis. Human genetic studies have provided new information on the physiological role of SPCA1. Loss of one functional copy of the SPCA1 (ATP2C1) gene causes Hailey-Hailey disease, a skin disorder arising in the adult age with recurrent vesicles and erosions in the flexural areas. Here, we review recent experimental evidence showing that the Golgi apparatus plays a much more important role in intracellular ion homeostasis than previously anticipated. Copyright 2004 Elsevier Inc.Entities:
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Year: 2004 PMID： 15336968 DOI： 10.1016/j.bbrc.2004.07.128
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575