Literature DB >> 15336632

A DNA repair gene of Caenorhabditis elegans: a homolog of human XPF.

Hye Kyung Park1, Dongchul Suh, Moonjung Hyun, Hyeon-Sook Koo, Byungchan Ahn.   

Abstract

The xeroderma pigmentosum complementation group F (XPF) protein is a structure-specific endonuclease in a complex with ERCC1 and is essential for nucleotide excision repair (NER). We report a single cDNA of Caenorhabditis elegans (C. elegans) encoding highly similar protein to human XPF and other XPF members. We propose to name the corresponding C. elegans gene xpf. Messenger RNA for C. elegans xpf is 5'-tagged with a SL2 splice leader, suggesting an operon-like expression for xpf. Using RNAi, we showed that loss of C. elegans xpf function caused hypersensitivity to ultra-violet (UV) irradiation, as observed in enhanced germ cell apoptosis and increased embryonic lethality. This study suggests that C. elegans xpf is conserved in evolution and plays a role in the repair of UV-damaged DNA in C. elegans.

Entities:  

Mesh：

Substances：

Year:  2004        PMID： 15336632     DOI： 10.1016/j.dnarep.2004.04.008

Source DB:  PubMed          Journal:  DNA Repair (Amst)        ISSN： 1568-7856


  12 in total

1.  Involvement of global genome repair, transcription coupled repair, and chromatin remodeling in UV DNA damage response changes during development.

Authors:  Hannes Lans; Jurgen A Marteijn; Björn Schumacher; Jan H J Hoeijmakers; Gert Jansen; Wim Vermeulen
Journal:  PLoS Genet       Date:  2010-05-06       Impact factor: 5.917

2.  Identification of intermediate-size non-coding RNAs involved in the UV-induced DNA damage response in C. elegans.

Authors:  Aqian Li; Guifeng Wei; Yunfei Wang; Ying Zhou; Xian-en Zhang; Lijun Bi; Runsheng Chen
Journal:  PLoS One       Date:  2012-11-07       Impact factor: 3.240

3.  Nucleotide Excision Repair in Caenorhabditis elegans.

Authors:  Hannes Lans; Wim Vermeulen
Journal:  Mol Biol Int       Date:  2011-08-17

4.  Single-nucleotide base excision repair DNA polymerase activity in C. elegans in the absence of DNA polymerase β.

Authors:  Kenjiro Asagoshi; Wade Lehmann; Elena K Braithwaite; Lucas Santana-Santos; Rajendra Prasad; Jonathan H Freedman; Bennett Van Houten; Samuel H Wilson
Journal:  Nucleic Acids Res       Date:  2011-09-14       Impact factor: 16.971

5.  TILLING is an effective reverse genetics technique for Caenorhabditis elegans.

Authors:  Erin J Gilchrist; Nigel J O'Neil; Ann M Rose; Monique C Zetka; George W Haughn
Journal:  BMC Genomics       Date:  2006-10-18       Impact factor: 3.969

6.  Caenorhabditis elegans HIM-18/SLX-4 interacts with SLX-1 and XPF-1 and maintains genomic integrity in the germline by processing recombination intermediates.

Authors:  Takamune T Saito; Jillian L Youds; Simon J Boulton; Monica P Colaiácovo
Journal:  PLoS Genet       Date:  2009-11-20       Impact factor: 5.917

7.  SLX-1 is required for maintaining genomic integrity and promoting meiotic noncrossovers in the Caenorhabditis elegans germline.

Authors:  Takamune T Saito; Firaz Mohideen; Katherine Meyer; J Wade Harper; Monica P Colaiácovo
Journal:  PLoS Genet       Date:  2012-08-23       Impact factor: 5.917

8.  Decline of nucleotide excision repair capacity in aging Caenorhabditis elegans.

Authors:  Joel N Meyer; Windy A Boyd; Gregory A Azzam; Astrid C Haugen; Jonathan H Freedman; Bennett Van Houten
Journal:  Genome Biol       Date:  2007       Impact factor: 13.583

Review 9.  Caenorhabditis elegans: an emerging model in biomedical and environmental toxicology.

Authors:  Maxwell C K Leung; Phillip L Williams; Alexandre Benedetto; Catherine Au; Kirsten J Helmcke; Michael Aschner; Joel N Meyer
Journal:  Toxicol Sci       Date:  2008-06-19       Impact factor: 4.849

10.  Longevity and resistance to stress correlate with DNA repair capacity in Caenorhabditis elegans.

Authors:  Moonjung Hyun; Jihyun Lee; Kyungjin Lee; Alfred May; Vilhelm A Bohr; Byungchan Ahn
Journal:  Nucleic Acids Res       Date:  2008-01-18       Impact factor: 16.971
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.