| Literature DB >> 15336505 |
Vera L Bonilha, Sanjoy K Bhattacharya, Karen A West, John S Crabb, Jian Sun, Mary E Rayborn, Maria Nawrot, John C Saari, John W Crabb.
Abstract
The interaction of cellular retinaldehyde-binding protein (CRALBP) with ERM (ezrin, radixin, moesin)-binding phosphoprotein 50 (EBP50) in retinal pigment epithelium (RPE) microsomes has led to the hypothesis that a retinoid-processing protein complex exists in apical RPE. Mouse RPE apical processes were isolated on wheat germ agglutinin-coated agarose beads. Proteomic analyses of the isolated apical RPE demonstrated the presence of CRALBP, EBP50, 11-cis-retinol dehydrogenase, cellular retinol-binding protein 1, and interphotoreceptor retinoid-binding protein. The results support the hypothesis that a visual cycle protein complex may serve in the localization and release of 11-cis-retinoid in the apical RPE.Entities:
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Year: 2004 PMID： 15336505 DOI： 10.1016/j.exer.2004.04.001
Source DB: PubMed Journal: Exp Eye Res ISSN： 0014-4835 Impact factor: 3.467