| Literature DB >> 15336373 |
Y Ravindra Kumar1, G Ramulu, V V Vevakanand, Gopal Vaidyanathan, Keesari Srinivas, M Kishore Kumar, K Mukkanti, M Satyanarayana Reddy, S Venkatraman, M V Suryanarayana.
Abstract
An isocratic chiral HPLC method was developed for the separation of tolterodine tartarate enantiomers. The mobile phase consists of n-hexane and isopropyl alcohol in the ratio of 980:20 (v/v) with 1 ml diethylamine and 0.6 ml trifluoroacetic acid. Chiralcel OD-H (250 mm x 4.6mm) column was used at constant room temperature. Flow rate was kept at 0.5 ml/min. This method is capable of detecting the S-isomer up to 0.1 microg/ml. The method was validated in terms of linearity, precision, limit of detection (LOD) and limit of quantification (LOQ).Entities:
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Year: 2004 PMID： 15336373 DOI： 10.1016/j.jpba.2004.03.026
Source DB: PubMed Journal: J Pharm Biomed Anal ISSN： 0731-7085 Impact factor: 3.935