Literature DB >> 15333648

The detection of circulating breast cancer cells in blood.

A M Gilbey1, D Burnett, R E Coleman, I Holen.   

Abstract

At present, sampling of the lymph nodes or bone marrow for the detection of regions of metastatic disease in patients with breast cancer can only be undertaken at the time of initial diagnosis and surgery. However, the sampling of these tissues and the methods used are inaccurate, time consuming, and cannot be used for easy routine screening to determine disease recurrence and response to treatment. Because of the problems encountered with current methods and tissues sampled at the time of breast cancer diagnosis, this review discusses the urgent requirement for and potential development of a quick, simple, and accurate diagnostic test utilising the haematogenous system, a source of circulating tumour cells in patients with breast cancer, and highly sensitive molecular biological techniques, such as reverse transcription polymerase chain reaction. In addition, this review also highlights potential problems that may be encountered and should be avoided when devising such a test.

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Year:  2004        PMID： 15333648      PMCID： PMC1770416          DOI： 10.1136/jcp.2003.013755

Source DB:  PubMed          Journal:  J Clin Pathol        ISSN： 0021-9746            Impact factor:   3.411


  95 in total

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3.  Circulating breast cancer cells are frequently apoptotic.

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4.  High percentage of false-positive results of cytokeratin 19 RT-PCR in blood: a model for the analysis of illegitimate gene expression.

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7.  Molecular detection of cancer cells in bone marrow and peripheral blood of patients with operable breast cancer. Comparison of CK19, MUC1 and CEA using RT-PCR.

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2.  Specific detection of cytokeratin 20-positive cells in blood of colorectal and breast cancer patients by a high sensitivity real-time reverse transcriptase-polymerase chain reaction method.

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5.  Molecular markers in peripheral blood of Iranian women with breast cancer.

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7.  CYP17 gene polymorphism and its association with high-risk north Indian breast cancer patients.

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10.  Flow cytometric analysis of CK19 expression in the peripheral blood of breast carcinoma patients: relevance for circulating tumor cell detection.

Authors:  Lili Wang; Yanyan Wang; Yajing Liu; Min Cheng; Xu Wu; Haiming Wei
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