Literature DB >> 15332863

Aureoverticillactam, a novel 22-atom macrocyclic lactam from the marine actinomycete Streptomyces aureoverticillatus.

Scott S Mitchell1, Benjamin Nicholson, Sy Teisan, Kin S Lam, Barbara C M Potts.   

Abstract

During the course of our screening program designed to discover novel anticancer and anti-infective agents from marine microorganisms, a strain of Streptomyces aureoverticillatus (NPS001583) isolated from a marine sediment was found to produce a novel macrocyclic lactam with cytotoxicity against various tumor cell lines. Using extensive MS, UV, and NMR spectral analyses, the structure has been established as compound 1, aureoverticillactam, a 22-atom macrocyclic lactam incorporating both triene and tetraene conjugated olefins.

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Year:  2004        PMID： 15332863     DOI： 10.1021/np049970g

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  12 in total

1.  Proteasome regulator marizomib (NPI-0052) exhibits prolonged inhibition, attenuated efflux, and greater cytotoxicity than its reversible analogs.

Authors:  Amanda Obaidat; Jeffrey Weiss; Brett Wahlgren; Rama R Manam; Venkat R Macherla; Katherine McArthur; Ta-Hsiang Chao; Michael A Palladino; G Kenneth Lloyd; Barbara C Potts; Salvatore J Enna; Saskia T C Neuteboom; Bruno Hagenbuch
Journal:  J Pharmacol Exp Ther       Date:  2011-02-08       Impact factor: 4.030

2.  Bioactive compounds from marine actinomycetes.

Authors:  Renu Solanki; Monisha Khanna; Rup Lal
Journal:  Indian J Microbiol       Date:  2009-01-08       Impact factor: 2.461

3.  Targeting mitochondrial factor Smac/DIABLO as therapy for multiple myeloma (MM).

Authors:  Dharminder Chauhan; Paola Neri; Mugdha Velankar; Klaus Podar; Teru Hideshima; Mariateresa Fulciniti; Pierfrancesco Tassone; Noopur Raje; Constantine Mitsiades; Nicholas Mitsiades; Paul Richardson; Leigh Zawel; Mary Tran; Nikhil Munshi; Kenneth C Anderson
Journal:  Blood       Date:  2006-10-10       Impact factor: 22.113

Review 4.  Polyene Macrolactams from Marine and Terrestrial Sources: Structure, Production Strategies, Biosynthesis and Bioactivities.

Authors:  Wei Zhao; Hong Jiang; Xiao-Wan Liu; Jian Zhou; Bin Wu
Journal:  Mar Drugs       Date:  2022-05-27       Impact factor: 6.085

Review 5.  Antitumor compounds from marine actinomycetes.

Authors:  Carlos Olano; Carmen Méndez; José A Salas
Journal:  Mar Drugs       Date:  2009-06-11       Impact factor: 5.118

6.  Marine Bacterial Compounds Evaluated by In Silico Studies as Antipsychotic Drugs Against Schizophrenia.

Authors:  Dhinesh Kumar Thiyagarajamoorthy; Charli Deepak Arulanandam; Hans-Uwe Dahms; Santhosh Gokul Murugaiah; Muthukumar Krishnan; Arthur James Rathinam
Journal:  Mar Biotechnol (NY)       Date:  2018-07-18       Impact factor: 3.619

7.  Marine Microorganism-Derived Macrolactins Inhibit Inflammatory Mediator Effects in LPS-Induced Macrophage and Microglial Cells by Regulating BACH1 and HO-1/Nrf2 Signals through Inhibition of TLR4 Activation.

Authors:  Eun-Nam Kim; Ming Gao; Hyukjae Choi; Gil-Saeng Jeong
Journal:  Molecules       Date:  2020-02-04       Impact factor: 4.411

Review 8.  Deep Hypersaline Anoxic Basins as Untapped Reservoir of Polyextremophilic Prokaryotes of Biotechnological Interest.

Authors:  Stefano Varrella; Michael Tangherlini; Cinzia Corinaldesi
Journal:  Mar Drugs       Date:  2020-01-30       Impact factor: 5.118

9.  Phaeochromycins F-H, three new polyketide metabolites from Streptomyces sp. DSS-18.

Authors:  Jian Li; Chun-Hua Lu; Bao-Bing Zhao; Zhong-Hui Zheng; Yue-Mao Shen
Journal:  Beilstein J Org Chem       Date:  2008-12-02       Impact factor: 2.883

10.  Antitumor Effects and Related Mechanisms of Penicitrinine A, a Novel Alkaloid with a Unique Spiro Skeleton from the Marine Fungus Penicillium citrinum.

Authors:  Qin-Ying Liu; Tong Zhou; Yang-Yang Zhao; Li Chen; Mei-Wei Gong; Qi-Wen Xia; Min-Gang Ying; Qiu-Hong Zheng; Qi-Qing Zhang
Journal:  Mar Drugs       Date:  2015-07-31       Impact factor: 5.118
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