| Literature DB >> 15332711 |
H M Ziglam1, I Daniels, R G Finch.
Abstract
It has been shown that some antibiotics can modify cytokine production. We have examined the effect of rifampicin on secretion of interleukin-1beta (IL-1beta), IL-6, IL-10, and tumor necrosis factor alpha (TNF-alpha) by lipopolysaccharide (LPS)-stimulated or heat killed staphylococci (Pansorbin) stimulated monocytes. Secretion of IL-1beta and TNF-a were significantly inhibited (P<0.002) whereas secretion of IL-6 and IL-10 were significantly increased (P<0.003) by rifampicin treated mononuclear cells. Rifampicin had immunomodulatory effects through its capacity to alter the secretion of tested cytokines by human monocytes.Entities:
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Year: 2004 PMID: 15332711 DOI: 10.1179/joc.2004.16.4.357
Source DB: PubMed Journal: J Chemother ISSN: 1120-009X Impact factor: 1.714