Literature DB >> 15332592

The expression of CD44 in archival paraffin embedded interface tissues of failed orthopaedic implants.

Taneisha McFarlane1, P A Revell.   

Abstract

CD44 hyaluronan receptor is present on large number of different cell type. It acts as one of the adhesion proteins, binding to hyaluronan and is known to play a part in cell migration from vessels in inflammation. The aim of this study was to examine the presence and distribution of CD44 in interface membrane in aseptic loosening. Immunohistochemistry (IHC) using human anti-mouse CD44 antibody studied 20 aseptically loosened interface samples. Extracted protein from all cases was examined by Western blot and RT-PCR. CD44 was detected in 85% of interfaces by IHC and the presence of protein confirmed by blotting and RT-PCR, which showed the mRNA level for CD44. CD44 was expressed by macrophage, multinucleated giant cells, mast cells and lymphocytes. Further studies are needed to characterise the role of this molecule in the inflammatory response to wear debris in aseptic loosening.

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Year:  2004        PMID： 15332592     DOI： 10.1023/b:jmsm.0000021094.50889.5c

Source DB:  PubMed          Journal:  J Mater Sci Mater Med        ISSN： 0957-4530            Impact factor:   3.896


  22 in total

1.  Hyaluronan synthases, hyaluronan, and its CD44 receptor in tissue around loosened total hip prostheses.

Authors:  Y T Konttinen; T F Li; J Mandelin; M Ainola; J Lassus; I Virtanen; S Santavirta; M Tammi; R Tammi
Journal:  J Pathol       Date:  2001-07       Impact factor: 7.996

2.  Production and distribution of interleukin 15 and its receptors (IL-15Ralpha and IL-R2beta) in the implant interface tissues obtained during revision of failed total joint replacement.

Authors:  S Saeed; P A Revell
Journal:  Int J Exp Pathol       Date:  2001-06       Impact factor: 1.925

3.  Neovascularisation and the induction of cell adhesion molecules in response to degradation products from orthopaedic implants.

Authors:  N al-Saffar; J T Mah; Y Kadoya; P A Revell
Journal:  Ann Rheum Dis       Date:  1995-03       Impact factor: 19.103

Review 4.  Biological reaction to debris in relation to joint prostheses.

Authors:  P A Revell; N al-Saffar; A Kobayashi
Journal:  Proc Inst Mech Eng H       Date:  1997       Impact factor: 1.617

5.  Type IV collagen and laminin in the synovial intimal layer: an immunohistochemical study.

Authors:  L E Pollock; P Lalor; P A Revell
Journal:  Rheumatol Int       Date:  1990       Impact factor: 2.631

6.  CD44 is the physiological trigger of Fas up-regulation on rheumatoid synovial cells.

Authors:  K Fujii; Y Fujii; S Hubscher; Y Tanaka
Journal:  J Immunol       Date:  2001-08-01       Impact factor: 5.422

Review 7.  Extracellular matrix of the synovial intimal cell layer.

Authors:  P A Revell; N al-Saffar; S Fish; D Osei
Journal:  Ann Rheum Dis       Date:  1995-05       Impact factor: 19.103

8.  Direct activation of mast cells by prosthetic biomaterial particles.

Authors:  N Al-Saffar; H Iwaki; P A Revell
Journal:  J Mater Sci Mater Med       Date:  1998-12       Impact factor: 3.896

9.  Involvement of CD44 in induction of matrix metalloproteinases by a COOH-terminal heparin-binding fragment of fibronectin in human articular cartilage in culture.

Authors:  Tadashi Yasuda; A Robin Poole; Makoto Shimizu; Takefumi Nakagawa; Sohel M Julovi; Hirokazu Tamamura; Nobutaka Fujii; Takashi Nakamura
Journal:  Arthritis Rheum       Date:  2003-05

10.  Implication of CD44 in adhesion-mediated overproduction of TGF-beta and IL-1 in monocytes from patients with bone marrow fibrosis.

Authors:  P Rameshwar; V T Chang; P Gascón
Journal:  Br J Haematol       Date:  1996-04       Impact factor: 6.998
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  4 in total

Review 1.  The combined role of wear particles, macrophages and lymphocytes in the loosening of total joint prostheses.

Authors:  Peter A Revell
Journal:  J R Soc Interface       Date:  2008-11-06       Impact factor: 4.118

2.  Evidence for active antigen presentation by monocyte/macrophages in response to stimulation with particles: the expression of NFκB transcription factors and costimulatory molecules.

Authors:  Huwaidha Altaf; Peter A Revell
Journal:  Inflammopharmacology       Date:  2013-05-14       Impact factor: 4.473

Review 3.  Systemic and local toxicity of metal debris released from hip prostheses: A review of experimental approaches.

Authors:  Divya Rani Bijukumar; Abhijith Segu; Júlio C M Souza; XueJun Li; Mark Barba; Louis G Mercuri; Joshua J Jacobs; Mathew Thoppil Mathew
Journal:  Nanomedicine       Date:  2018-01-12       Impact factor: 5.307

4.  Wear particles derived from metal hip implants induce the generation of multinucleated giant cells in a 3-dimensional peripheral tissue-equivalent model.

Authors:  Debargh K Dutta; Pushya A Potnis; Kelly Rhodes; Steven C Wood
Journal:  PLoS One       Date:  2015-04-20       Impact factor: 3.240
  4 in total

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