BACKGROUND AND PURPOSE: Familial occurrence of intracranial aneurysms suggests a genetic factor in the development of these aneurysms. In this study, we present the identification of a susceptibility locus for the development of intracranial aneurysms detected by a genome-wide linkage approach in a large consanguineous pedigree. METHODS: Patients with clinical signs and symptoms of intracranial aneurysms, confirmed by radiological, surgical, or postmortem investigations, were included in the study. Magnetic resonance angiography was used to detect asymptomatic aneurysms in relatives. RESULTS: Seven out of 20 siblings had an intracranial aneurysm. Genome-wide multipoint linkage analysis showed a significant logarithm of the odds score of 3.55. CONCLUSIONS: In a large consanguineous pedigree intracranial aneurysms are linked to chromosome 2p13 in a region between markers D2S2206 and D2S2977.
BACKGROUND AND PURPOSE: Familial occurrence of intracranial aneurysms suggests a genetic factor in the development of these aneurysms. In this study, we present the identification of a susceptibility locus for the development of intracranial aneurysms detected by a genome-wide linkage approach in a large consanguineous pedigree. METHODS:Patients with clinical signs and symptoms of intracranial aneurysms, confirmed by radiological, surgical, or postmortem investigations, were included in the study. Magnetic resonance angiography was used to detect asymptomatic aneurysms in relatives. RESULTS: Seven out of 20 siblings had an intracranial aneurysm. Genome-wide multipoint linkage analysis showed a significant logarithm of the odds score of 3.55. CONCLUSIONS: In a large consanguineous pedigree intracranial aneurysms are linked to chromosome 2p13 in a region between markers D2S2206 and D2S2977.
Authors: D J Verlaan; M-P Dubé; J St-Onge; A Noreau; J Roussel; N Satgé; M C Wallace; G A Rouleau Journal: J Med Genet Date: 2006-06 Impact factor: 6.318
Authors: D Woo; J Khoury; M M Haverbusch; P Sekar; M L Flaherty; D O Kleindorfer; B M Kissela; C J Moomaw; R Deka; J P Broderick Journal: Neurology Date: 2009-01-06 Impact factor: 9.910
Authors: Tatiana Foroud; Laura Sauerbeck; Robert Brown; Craig Anderson; Daniel Woo; Dawn Kleindorfer; Matthew L Flaherty; Ranjan Deka; Richard Hornung; Irene Meissner; Joan E Bailey-Wilson; Guy Rouleau; E Sander Connolly; Dongbing Lai; Daniel L Koller; John Huston; Joseph P Broderick Journal: Stroke Date: 2008-03-06 Impact factor: 7.914
Authors: Brian V Nahed; Askin Seker; Bulent Guclu; Ali K Ozturk; Karin Finberg; Abigail A Hawkins; Michael L DiLuna; Matthew State; Richard P Lifton; Murat Gunel Journal: Am J Hum Genet Date: 2004-11-11 Impact factor: 11.025