| Literature DB >> 15331180 |
Tatsuya Kato1, Masaki Miyamoto, Kentaro Kato, Yasushi Cho, Tomoo Itoh, Toshiaki Morikawa, Shunichi Okushiba, Satoshi Kondo, Toshiro Ohbuchi, Hiroyuki Katoh.
Abstract
Caveolin-1 has been implicated in cellular transformation and tumorigenesis. We assessed lung cancer specimens for caveolin-1 expression immunohistochemistry. A majority of the cell types in the lung and the bronchial epithelium normally exhibited positive staining for caveolin-1. In adenocarcinomas (ADs) of positive staining for caveolin-1, pT1 tumors exhibited significantly higher staining than pT2-pT4 tumors (P=0.0240). In squamous cell carcinomas (SCCs), pT1-pT2 tumors expressed significantly lower expression levels than pT3-pT4 tumors (P=0.0175). In AD, loss of caveolin-1 may be essential for tumor extension and dedifferentiation. In contrast, caveolin-1 overexpression may be correlated with tumor extension in SCC.Entities:
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Year: 2004 PMID： 15331180 DOI： 10.1016/j.canlet.2004.04.017
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679