| Literature DB >> 15331169 |
Yan An1, Zenglin Gao, Zhongwen Wang, Shaohe Yang, Jianfen Liang, Yan Feng, Koichi Kato, Masayuki Nakano, Shoji Okada, Kenzo Yamanaka.
Abstract
The appearance of 8-oxo-2'-deoxyguanosine (8-oxodG) was examined immunohistochemically using an 8-oxodG-monoclonal antibody in 28 cases of arsenic-related human skin tumors and in 20 cases of arsenic-unrelated human skin cancer to determine if the induction of oxidative stress participates in skin tumorigenesis caused by arsenics. The rate of 8-oxodG-positive was significantly higher in arsenic-related human skin cancer (28 of 28, 100%) than in arsenic-unrelated human skin cancer (3 of 20, 15%, P<0.01 by Chi2 test). Moreover, in all the arsenic-related skin samples, 8-oxodG was detected not only in tumor tissues but also in keratosis and normal tissues. These results suggest that the induction of oxidative stress may play an important role in arsenic carcinogenesis.Entities:
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Year: 2004 PMID： 15331169 DOI： 10.1016/j.canlet.2004.04.005
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679